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Field	Query

	Field	Term

General Information:

Id:	3,064
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Homo sapiens
Gender:	male
Publication type:	article
Reference:	Ronnemaa E et al.(2008) Impaired insulin secretion increases the risk of Alzheimer disease Neurology 71: 1065-1071 [PMID: 18401020]

Interaction Information:

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28098	phenotype low insulin secretion involved in cellular response to glucose stimulus increases_activity of disease Alzheimer disease

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28099	gene/protein mutant APOE (isoform E4) increases_activity of disease Alzheimer disease

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28100	phenotype impaired glucose tolerance increases_activity of disease Vascular dementia

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28101	phenotype impaired glucose tolerance NOT increases_activity of disease Alzheimer disease

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28102	disease Insulin resistance increases_activity of disease Dementia

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28103	disease Insulin resistance decreases_activity of process cognition

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28104	phenotype impaired glucose tolerance increases_activity of disease Dementia

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28105	phenotype impaired glucose tolerance decreases_activity of process cognition

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28106	phenotype low insulin secretion involved in cellular response to glucose stimulus increases_activity of disease Dementia

Comment	The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description Interaction-ID: 28107	phenotype low insulin secretion involved in cellular response to glucose stimulus decreases_activity of process cognition

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