CIDeRplusGeneral Information:
| Id: | 2,994 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| transgenic mouse conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in beta-cells | |
| article | |
| Reference: | Hu He KH et al.(2011) In vivo conditional Pax4 overexpression in mature islet beta-cells prevents stress-induced hyperglycemia in mice Diabetes 60: 1705-1715 [PMID: 21521872] |
Interaction Information:
| Comment | Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor kappaB target genes while increasing Bcl-2 levels. Furthermore, it promotes dedifferentiation and proliferation of beta-cells through MafA repression, with a concomitant increase in Cdk4 and c-myc expression. |
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Formal Description Interaction-ID: 27263 |
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