CIDeRplusGeneral Information:
| Id: | 2,994 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| transgenic mouse conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in beta-cells | |
| article | |
| Reference: | Hu He KH et al.(2011) In vivo conditional Pax4 overexpression in mature islet beta-cells prevents stress-induced hyperglycemia in mice Diabetes 60: 1705-1715 [PMID: 21521872] |
Interaction Information:
| Comment | In transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in beta-cells, Pax4 but not Pax4R129W protected animals against streptozotocin-induced hyperglycemia and isolated islets from cytokine-mediated beta-cell apoptosis. Cytochrome C release was abrogated in Pax4 islets treated with cytokines. Interleukin-1beta transcript levels were suppressed in Pax4 islets, whereas they were increased along with NOS2 in Pax4R129W islets. Bcl-2, Cdk4, and c-myc expression levels were increased in Pax4 islets while MafA, insulin, and GLUT2 transcript levels were suppressed in both animal models. |
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Formal Description Interaction-ID: 27259 |
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