General Information:

Id: 2,994 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
transgenic mouse conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in beta-cells
article
Reference: Hu He KH et al.(2011) In vivo conditional Pax4 overexpression in mature islet beta-cells prevents stress-induced hyperglycemia in mice Diabetes 60: 1705-1715 [PMID: 21521872]

Interaction Information:

Comment In transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in beta-cells, Pax4 but not Pax4R129W protected animals against streptozotocin-induced hyperglycemia and isolated islets from cytokine-mediated beta-cell apoptosis. Cytochrome C release was abrogated in Pax4 islets treated with cytokines. Interleukin-1beta transcript levels were suppressed in Pax4 islets, whereas they were increased along with NOS2 in Pax4R129W islets. Bcl-2, Cdk4, and c-myc expression levels were increased in Pax4 islets while MafA, insulin, and GLUT2 transcript levels were suppressed in both animal models.
Formal Description
Interaction-ID: 27251

gene/protein

PAX4

affects_activity of

process

type B pancreatic cell apoptotic process

if cytokine-mediated
Comment In transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (Pax4R129W) in beta-cells, Pax4 but not Pax4R129W protected animals against streptozotocin-induced hyperglycemia and isolated islets from cytokine-mediated beta-cell apoptosis. Cytochrome C release was abrogated in Pax4 islets treated with cytokines. Interleukin-1beta transcript levels were suppressed in Pax4 islets, whereas they were increased along with NOS2 in Pax4R129W islets. Bcl-2, Cdk4, and c-myc expression levels were increased in Pax4 islets while MafA, insulin, and GLUT2 transcript levels were suppressed in both animal models.
Formal Description
Interaction-ID: 27259

gene/protein

PAX4

affects_expression of

gene/protein

SLC2A2

Drugbank entries Show/Hide entries for SLC2A2
Comment Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor kappaB target genes while increasing Bcl-2 levels. Furthermore, it promotes dedifferentiation and proliferation of beta-cells through MafA repression, with a concomitant increase in Cdk4 and c-myc expression.
Formal Description
Interaction-ID: 27260

gene/protein

PAX4

decreases_activity of

process

type B pancreatic cell apoptotic process

Comment Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor kappaB target genes while increasing Bcl-2 levels. Furthermore, it promotes dedifferentiation and proliferation of beta-cells through MafA repression, with a concomitant increase in Cdk4 and c-myc expression.
Formal Description
Interaction-ID: 27261

gene/protein

PAX4

decreases_activity of

complex/PPI

NF-kappaB complex

Comment Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor kappaB target genes while increasing Bcl-2 levels. Furthermore, it promotes dedifferentiation and proliferation of beta-cells through MafA repression, with a concomitant increase in Cdk4 and c-myc expression.
Formal Description
Interaction-ID: 27263

gene/protein

PAX4

increases_activity of

process

type B pancreatic cell proliferation