General Information:

Id: 278
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0004488 NSC-34 cell
article
Reference: Kieran D et al.(2008) Control of motoneuron survival by angiogenin J. Neurosci. 28 [PMID: 19109488]

Interaction Information:

Comment WT-ANG transfected cells showed significantly reduced levels of ER stress-induced apoptosis.
Formal Description
Interaction-ID: 1123

gene/protein

ANG

decreases_activity of

process

neuron apoptotic process

Drugbank entries Show/Hide entries for ANG
Comment Mutant ANG(K40I) transfected cells did not show reduced levels of ER stress-induced apoptosis.
Formal Description
Interaction-ID: 1124

gene/protein mutant

ANG-p.K40I

NOT decreases_activity of

process

neuron apoptotic process

Comment WT-ANG protein, but not K40I mutant angiogenin protein, elevated the levels of active pAkt-1 in NSC34 cells during trophic factor withdrawal.
Formal Description
Interaction-ID: 1129

gene/protein

ANG

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for ANG or AKT1
Comment WT-ANG protein, but not K40I mutant angiogenin protein, elevated the levels of active pAkt-1 in NSC34 cells during trophic factor withdrawal.
Formal Description
Interaction-ID: 1131

gene/protein mutant

ANG-p.K40I

NOT increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1