CIDeRplusGeneral Information:
| Id: | 2,306 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| homozygous db-/db- mouse from a C57BL/6 background | |
| BTO:0000131 blood plasma | |
| article | |
| Reference: | Altmaier E et al.(2008) Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication. Endocrinology 149: 3478-3489 [PMID: 18372322] |
Interaction Information:
| Comment | The diabetes phenotype reveals itself through high sugar concentrations and reduced concentrations of the glucogenic amino acids glycine, serine and alanine in diabetic mice when compared with the wild-type mice. This observation may be explained by an impaired uptake of glucose by insulin-resistant cells, which induces hepatic gluconeogenesis, a process that then consumes glucogenic amino acids to initiate the production of the glucose precursors pyruvate and 3-phosphoglycerate. |
|
Formal Description Interaction-ID: 19765 |
disease decreases_quantity of drug/chemical compound |
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