CIDeRplusGeneral Information:
| Id: | 2,185 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| cultured rat L6 muscle cells that overexpress GLUT4 | |
| article | |
| Reference: | Maddux BA et al.(2001) Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes 50: 404-410 [PMID: 11272154] |
Interaction Information:
| Comment | Oxidative stress caused a significant decrease (approximately 50%) in reduced glutathione concentration, along with the rapid activation of the stress-sensitive p38 mitogen-activated protein kinase. Pretreatment with LA prevented both of these events, coincident with protecting insulin action. |
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Formal Description Interaction-ID: 18304 |
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