CIDeRplusGeneral Information:
| Id: | 2,185 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| cultured rat L6 muscle cells that overexpress GLUT4 | |
| article | |
| Reference: | Maddux BA et al.(2001) Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes 50: 404-410 [PMID: 11272154] |
Interaction Information:
| Comment | When cells were exposed to glucose oxidase and glucose to generate H2O2 and cause oxidative stress, there was a marked decrease in insulin-stimulated glucose transport. Pretreatment with LA over the concentration range of 10-1,000 pmol/l protected the insulin effect from inhibition by H2O2. Both the R and S isomers of LA were equally effective. |
|
Formal Description Interaction-ID: 18300 |
|