CIDeRplusGeneral Information:
| Id: | 2,183 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| male | |
| 12-wk-old spontaneously hypertensive rats (SHR/NHsd, haplotype RT1k) | |
| article | |
| Reference: | Potenza MA et al.(2005) Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production Am. J. Physiol. Heart Circ. Physiol. 289: H813-H822 [PMID: 15792994] |
Interaction Information:
| Comment | Twelve-week-old male spontaneously hypertensive rats (SHR) were hypertensive and insulin resistant compared with control Wistar-Kyoto (WKY) rats. |
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Formal Description Interaction-ID: 18280 |
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| Comment | In WKY rats, insulin stimulated dose-dependent relaxation of mesenteric arteries precontracted with norepinephrine (NE) ex vivo. This depended on intact endothelium and was blocked by genistein, wortmannin, or N(omega)-nitro-l-arginine methyl ester (inhibitors of tyrosine kinase, PI3-kinase, and NO synthases, respectively). |
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Formal Description Interaction-ID: 18281 |
complex/PPI Insulin increases_activity of |
| Comment | In WKY rats, insulin stimulated dose-dependent relaxation of mesenteric arteries precontracted with norepinephrine (NE) ex vivo. This depended on intact endothelium and was blocked by genistein, wortmannin, or N(omega)-nitro-l-arginine methyl ester (inhibitors of insulin receptor tyrosine kinase, PI3-kinase, and NO synthases, respectively). |
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Formal Description Interaction-ID: 18282 |
complex/PPI Insulin receptor affects_activity of |
| Comment | In WKY rats, insulin stimulated dose-dependent relaxation of mesenteric arteries precontracted with norepinephrine (NE) ex vivo. This depended on intact endothelium and was blocked by genistein, wortmannin, or N(omega)-nitro-l-arginine methyl ester (inhibitors of insulin receptor tyrosine kinase, PI3-kinase, and NO synthases, respectively). |
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Formal Description Interaction-ID: 18283 |
complex/PPI Phosphatidylinositol 3-kinase affects_activity of |
| Comment | In WKY rats, insulin stimulated dose-dependent relaxation of mesenteric arteries precontracted with norepinephrine (NE) ex vivo. This depended on intact endothelium and was blocked by genistein, wortmannin, or N(omega)-nitro-l-arginine methyl ester (inhibitors of insulin receptor tyrosine kinase, PI3-kinase, and NO synthases, respectively). |
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Formal Description Interaction-ID: 18284 |
gene/protein NOS affects_activity of |
| Drugbank entries | Show/Hide entries for NOS |
| Comment | Vasodilation in response to insulin (but not ACh) was impaired by 20% in SHR. |
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Formal Description Interaction-ID: 18285 |
phenotype decreases_activity of |
| Comment | Vasodilation in response to insulin (but not ACh) was impaired by 20% in SHR. |
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Formal Description Interaction-ID: 18286 |
phenotype NOT decreases_activity of |
| Comment | Preincubation of arteries with insulin significantly reduced the contractile effect of norepinephrine (NE) by 20% in WKY but not SHR rats. |
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Formal Description Interaction-ID: 18287 |
drug/chemical compound increases_activity of |
| Comment | Preincubation of arteries with insulin significantly reduced the contractile effect of norepinephrine (NE) by 20% in WKY but not SHR rats. |
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Formal Description Interaction-ID: 18288 |
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| Comment | Preincubation of arteries with insulin significantly reduced the contractile effect of norepinephrine (NE) by 20% in WKY but not SHR rats. |
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Formal Description Interaction-ID: 18289 |
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| Comment | Insulin-stimulated endothelin-1 (ET-1) secretion is mediated by MAPK signaling. |
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Formal Description Interaction-ID: 18290 |
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