CIDeRplusGeneral Information:
| Id: | 2,167 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Rattus norvegicus | |
| article | |
| Reference: | Raasch W et al.(2001) Angiotensin converting enzyme inhibition improves cardiac neuronal uptake of noradrenaline in spontaneously hypertensive rats. J. Hypertens. 19: 1827-1833 [PMID: 11593103] |
Interaction Information:
| Comment | Acute administration of fosinoprilat to isolated perfused rat hearts increased the extraction of [3H]-noradrenaline from the perfusate by 39%. Treatment (14 days) of spontaneously hypertensive rats (SHR) with fosinopril enhanced the cardiac uptake of i.v. administered [3H]-noradrenaline by 28%. The endogenous left ventricular content of noradrenaline was increased by 49% after an antihypertensive treatment of SHR with fosinopril. Identical increases in cardiac noradrenaline stores (53%) were observed in SHR treated with a blood pressure ineffective dose of fosinopril. The myocardial content of adrenaline was increased in parallel to noradrenaline after both dose regimes. |
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Formal Description Interaction-ID: 18145 |
drug/chemical compound increases_quantity of drug/chemical compound |