CIDeRplusGeneral Information:
| Id: | 216 |
| Diseases: |
Epilepsy, temporal lobe
|
| Rattus norvegicus | |
| Sprague‚ÄďDawley rat | |
| BTO:0000601 hippocampus | |
| article | |
| Reference: | Liu XY et al.(2008) Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy. Proteomics 8: 582-603 [PMID: 18186018] |
Interaction Information:
| Comment | The vimentin (VIM) was down-pegulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 851 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The apha-actin-1 (ACTA1) was down-pegulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 852 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or ACTA1 |
| Comment | The enolase 2 (ENO2) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 854 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or ENO2 |
| Comment | The pyruvate dehydrogenase E1 (PDHB) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 855 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or PDHB |
| Comment | The beta-actin (ACTB) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 857 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | 60 kDA heat-shock protein (HSPD1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 858 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The fructose-bisphosphate aldolase A (ALDOA) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 874 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or ALDOA |
| Comment | The ribose-phosphate pyrophosphokinase I (PRPS1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 877 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The synaptosomal-associated protein, 25kDa, (SNAP25) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 878 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or SNAP25 |
| Comment | The Rho GDP-dissociation inhibitor 1 (ARHGDIA) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 879 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The lactoylglutathione lyase (GLO1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 880 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or GLO1 |
| Comment | The stathmin (STMN1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 881 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The nucleoside diphosphate kinase A (NME1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 882 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or NME1 |
| Comment | The low molecular weight phosphotyrosine protein phosphatase (ACP1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 898 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or ACP1 |
| Comment | The ubiquitin-conjugating enzyme E2 (UBE2N) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 899 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The hemoglobin subunit alpha-1/2 (HBA2) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 900 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The adenylate kinase isoenzyme 1 (AK1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 901 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or AK1 |
| Comment | The transgelin-3 (TAGLN3) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 903 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The NADH-dependent carbonyl reductase 1 (CBR1) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 904 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or CBR1 |
| Comment | The GST Mu I (GSTM5) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 905 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or GSTM5 |
| Comment | The hemoglobin subunit beta (HBB) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 906 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or HBB |
| Comment | The tubulin beta-2B chain (TUBB2B) was down-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 917 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or TUBB2B |
| Comment | The tubulin neurofilament triplet M protein (NEF3) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 988 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The heat shock protein HSP 90-beta (HSP90AB1) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 989 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or HSP90AB1 |
| Comment | The neuropilin-2 precursor (NRP2) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 991 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The heat shock 70 kDa protein 1B (HSPA1B) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 992 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The semaphorin-6C precursor (SEM6C) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 993 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The tubulin alpha-1 chain (TUBA1) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 995 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or TUBA4A |
| Comment | The tubulin alpha-2 chain (TUBA3) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 997 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or TUBA1A |
| Comment | The protein disulfide isomerase A6 precursor (PDIA6) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 1000 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The HOMER2 was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 1001 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The D-dopachrome decarboxylase (DDT) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 1003 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The pyruvate kinase isozymes M2 (PKM2) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 1004 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The SYN2 was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
|
Formal Description Interaction-ID: 1005 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The ATP synthase subunit beta, mitochondrial precursor (ATP5B) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 1006 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The voltage-dependent anion-selective channel protein 2 (VDAC2) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 1007 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or VDAC2 |
| Comment | The spectrin alpha chain (SPTAN1) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 1009 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The neurogranin (NRGN) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 1010 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The internexin neuronal intermediate filament protein alpha (INA) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 1011 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The RNA-binding protein Musashi homolog 1 (MSI1) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 1012 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | The cytochrome c oxidase subunit VIb isoform 1 (COX6B1) was up-regulated in rat hippocampus at the time point 12 h in the pilocarpine model of temporal lobe epilepsy. |
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Formal Description Interaction-ID: 1013 |
drug/chemical compound increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Pilocarpine or COX6B1 |