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Field	Query

	Field	Term

General Information:

Id:	2,072 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Mus musculus
Organism Model:	ApoE4 mouse
Publication type:	article
Reference:	Shenk JC et al.(2009) The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimers disease J. Neurol. Sci. 283: 199-206 [PMID: 19342064]

Interaction Information:

Comment	Compared to WT mice, CBF (cerebral blood flow) was significantly lower in ApoE4 6-month and 12-month mice.
Formal Description Interaction-ID: 16715	gene/protein mutant APOE (isoform E4) increases_activity of phenotype decreased brain blood flow rate in ApoE4 6-month and 12-month mice; compared to WT mouse

Comment	Compared to WT mice, CBF (cerebral blood flow) was significantly lower in ApoE4 6-month and 12-month mice.
Formal Description Interaction-ID: 16716	gene/protein mutant APOE (isoform E4) increases_activity of phenotype decreased cerebral blood flow rate in ApoE4 6-month and 12-month mice; compared to WT mouse

Comment	ApoE4 reduces CBF gradually to create brain hypoperfusion when compared to WT and the differences in CBF are greatest as animals age from 6 weeks to 12 months.
Formal Description Interaction-ID: 16717	gene/protein mutant APOE (isoform E4) increases_activity of phenotype brain hypoperfusion in ApoE4 6-month and 12-month mice; compared to WT mouse

Comment	The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse (a model of human Alzheimer disease) is shown.
Formal Description Interaction-ID: 16719	gene/protein mutant APOE (isoform E4) increases_activity of disease Alzheimer disease in APOE4 mice

Comment	Microvessels from ApoE4 mice show the stress reaction of vascular endothelium.
Formal Description Interaction-ID: 16751	gene/protein mutant APOE (isoform E4) increases_activity of process response to stress in APOE4 mouse microvessels

Comment	Microvessels from ApoE4 mice show the stress reaction of vascular endothelium.
Formal Description Interaction-ID: 16752	gene/protein mutant APOE (isoform E4) affects_activity of tissue/cell line vascular endothelium in APOE4 mouse microvessels

Comment	Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description Interaction-ID: 38965	gene/protein mutant APOE (isoform E4) decreases_activity of process learning or memory in APOE4 mice; if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid

Comment	Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description Interaction-ID: 95893	gene/protein mutant APOE (isoform E4) increases_activity of phenotype cognitive impairment in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid

Comment	Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description Interaction-ID: 95894	drug/chemical compound mitochondrial antioxidant decreases_activity of gene/protein mutant APOE (isoform E4) in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid

Comment	Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description Interaction-ID: 95895	drug/chemical compound Acetylcarnitine decreases_activity of gene/protein mutant APOE (isoform E4) in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid

Comment	Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description Interaction-ID: 95896	drug/chemical compound R-alpha-lipoic acid decreases_activity of gene/protein mutant APOE (isoform E4) in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid

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