CIDeRplusGeneral Information:
| Id: | 2,072 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Mus musculus | |
| ApoE4 mouse | |
| article | |
| Reference: | Shenk JC et al.(2009) The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimers disease J. Neurol. Sci. 283: 199-206 [PMID: 19342064] |
Interaction Information:
| Comment | ApoE4 reduces CBF gradually to create brain hypoperfusion when compared to WT and the differences in CBF are greatest as animals age from 6 weeks to 12 months. |
|
Formal Description Interaction-ID: 16717 |
gene/protein mutant increases_activity of phenotype brain hypoperfusion |