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Field	Query

	Field	Term

General Information:

Id:	204
Diseases:	Schizophrenia - [OMIM]
Organism:	Mus musculus
Organism Model:	HB-EGF KO mouse
Tissue/Cell line:	BTO:0000142 brain
Publication type:	article
Reference:	Oyagi A et al.(2009) Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice PLoS ONE 4: E7461 [PMID: 19829704]

Interaction Information:

Comment	HB-EGF null mouse shows diminished sensorimotor gating.
Formal Description Interaction-ID: 820	gene/protein HBEGF NOT affects_activity of phenotype reduced sensorimotor gating

Comment	HB-EGF KO mice spent significantly less time engaging in social contact than control mice.
Formal Description Interaction-ID: 822	gene/protein HBEGF affects_activity of process social behavior

Comment	In the prefrontal cortex and in the cerebellum DA (dopamine) level was lower in HB-EGF KO mice than in control mice.
Formal Description Interaction-ID: 824	gene/protein HBEGF NOT affects_quantity of drug/chemical compound Dopamine
Drugbank entries	Show/Hide entries for
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

Comment	The 5-HT (serotonin) level in the thalamus was also lower in HB-EGF KO mice than in control mice.
Formal Description Interaction-ID: 825	gene/protein HBEGF affects_quantity of drug/chemical compound Serotonin

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