General Information:

Id: 2,004
Diseases: Schizophrenia - [OMIM]
Homo sapiens
BTO:0000773 lymphoblastoid cell line
article
Reference: Rosenfeld M et al.(2011) Perturbation in mitochondrial network dynamics and in complex I dependent cellular respiration in schizophrenia Biol. Psychiatry 69: 980-988 [PMID: 21397211]

Interaction Information:

Comment The basal respiration of schizophrenia lymphoblastoids was significantly decreased (over 25%) compared to control cells from healthy subjects.
Formal Description
Interaction-ID: 15900

disease

Schizophrenia

decreases_activity of

process

cellular respiration

Comment The dopamine (DA) inhibited mitochondrial respiration of schizophrenia lymphoblastoids twice as much as in control cells.
Formal Description
Interaction-ID: 15901

drug/chemical compound

Dopamine

decreases_activity of

process

cellular respiration

as much as in control cells
Drugbank entries Show/Hide entries for Dopamine
Comment In the lymphoblastoids NDUFV2 was down-regulated in schizophrenia compared with control whereas NDUFS1 was significantly up-regulated, and NDUFV1 showed a tendency toward up-regulation.
Formal Description
Interaction-ID: 15902

disease

Schizophrenia

decreases_quantity of

gene/protein

NDUFV2

Drugbank entries Show/Hide entries for NDUFV2
Comment In the lymphoblastoids NDUFV2 was down-regulated in schizophrenia compared with control whereas NDUFS1 was significantly up-regulated, and NDUFV1 showed a tendency toward up-regulation.
Formal Description
Interaction-ID: 15903

disease

Schizophrenia

increases_quantity of

gene/protein

NDUFS1

Drugbank entries Show/Hide entries for NDUFS1
Comment In the lymphoblastoids NDUFV2 was down-regulated in schizophrenia compared with control whereas NDUFS1 was significantly up-regulated, and NDUFV1 showed a tendency toward up-regulation.
Formal Description
Interaction-ID: 15904

disease

Schizophrenia

increases_quantity of

gene/protein

NDUFV1

Drugbank entries Show/Hide entries for NDUFV1
Comment In lymphoblastoids, haloperidol inhibited complex I driven respiration to a similar extent in both schizophrenia and the control cohorts.
Formal Description
Interaction-ID: 15905

drug/chemical compound

Haloperidol

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in schizophrenia cells
Drugbank entries Show/Hide entries for Haloperidol
Comment In lymphoblastoids, haloperidol inhibited complex I driven respiration to a similar extent in both schizophrenia and the control cohorts.
Formal Description
Interaction-ID: 15906

drug/chemical compound

Haloperidol

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in control healthy cells
Drugbank entries Show/Hide entries for Haloperidol
Comment The schizophrenia-derived cells had more filamentous mitochondria compared to the control cells.
Formal Description
Interaction-ID: 15907

disease

Schizophrenia

affects_activity of

process

mitochondrial fission