General Information:

Id: 1,957 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Gibson GE et al.(2008) Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimers disease Ann. N. Y. Acad. Sci. 1147: 221-232 [PMID: 19076444]

Interaction Information:

Comment Reductions in metabolism correlate with apolipoprotein E (APOE) epsilon4 gene dose and are progressive in late-middle-aged persons.
Formal Description
Interaction-ID: 15166

gene/protein mutant

APOE (isoform E4)

decreases_activity of

process

metabolic process

progressive in late-middle-aged persons