CIDeRplusGeneral Information:
| Id: | 1,902 |
| Diseases: |
Epilepsy
Status epilepticus |
| Rattus norvegicus | |
| BTO:0000601 hippocampus | |
| article | |
| Reference: | dos Santos PS et al.(2011) Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures Pharmacol. Biochem. Behav. 97: 531-536 [PMID: 21062633] |
Interaction Information:
| Comment | Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or alpha-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of alpha-lipoic acid. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. |
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Formal Description Interaction-ID: 14536 |
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| Comment | Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or alpha-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of alpha-lipoic acid. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. |
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Formal Description Interaction-ID: 14539 |
drug/chemical compound decreases_activity of |
| Comment | Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or alpha-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of alpha-lipoic acid. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. |
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Formal Description Interaction-ID: 14540 |
increases_activity of gene/protein |
| Drugbank entries | Show/Hide entries for CASP3 |
| Comment | Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or alpha-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of alpha-lipoic acid. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. |
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Formal Description Interaction-ID: 14541 |
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| Drugbank entries | Show/Hide entries for CASP3 |
| Comment | Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or alpha-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of alpha-lipoic acid. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. |
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Formal Description Interaction-ID: 14542 |
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| Drugbank entries | Show/Hide entries for AIFM1 |
| Comment | Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or alpha-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of alpha-lipoic acid. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. |
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Formal Description Interaction-ID: 14543 |
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| Drugbank entries | Show/Hide entries for AIFM1 |
| Comment | Wistar rats were injected intraperitoneally with 0.9% saline (control group), pilocarpine (400 mg/kg, pilocarpine group) alone, or alpha-lipoic acid (20 mg/kg) in association with pilocarpine (400 mg/kg) 30 min before administration of alpha-lipoic acid. Cell death was reduced in lipoic acid-treated rats. Cytosolic translocation of cytochrome c and subsequent activation of caspase-3 were reduced by lipoic acid treatment. AIF nuclear translocation and subsequent large-scale DNA fragmentation were also decreased in lipoic acid-treated rats. |
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Formal Description Interaction-ID: 14544 |
drug/chemical compound decreases_activity of process |
| Comment | The lipoic acid inhibits both caspase-dependent and -independent apoptotic pathways and may be neuroprotective against hippocampal damage during pilocarpine-induced seizures. |
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Formal Description Interaction-ID: 14545 |
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