General Information:

Id: 1,893 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Vance JE and Hayashi H(2010) Formation and function of apolipoprotein E-containing lipoproteins in the nervous system Biochim. Biophys. Acta 1801: 806-818 [PMID: 20170744]

Interaction Information:

Comment Individuals with one APOE4 isoform are 3 to 4 times as likely to develop AD as those without any APOE4, and people with two APOE4 alleles have a 12-fold higher risk of developing AD.
Formal Description
Interaction-ID: 14500

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Alzheimer disease

Comment The APOE4 allele is also associated with an accelerated development and progression of several other neurodegenerative conditions such as Parkinson's disease, multiple sclerosis, head trauma, cerebral hemorrhage and possibly stroke.
Formal Description
Interaction-ID: 14502

gene/protein mutant

APOE (isoform E4)

increases_activity of

phenotype

neurodegeneration

Comment The APOE isoform E4 allele is also associated with an accelerated development and progression of several other neurodegenerative conditions such as Parkinson's disease, multiple sclerosis, head trauma, cerebral hemorrhage and possibly stroke.
Formal Description
Interaction-ID: 14513

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Parkinson disease

Comment The APOE4 allele is also associated with an accelerated development and progression of several other neurodegenerative conditions such as Parkinson's disease, multiple sclerosis, head trauma, cerebral hemorrhage and possibly stroke.
Formal Description
Interaction-ID: 14514

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Multiple sclerosis

Comment The expression of human APOE4, rather than human APOE3, in mice impaired synaptogenesis.
Formal Description
Interaction-ID: 14519

gene/protein mutant

APOE (isoform E4)

affects_activity of

process

synapse assembly

Comment Memory and learning were impaired in apo E4 knock-in mice compared to apo E3 knock-in mice.
Formal Description
Interaction-ID: 14521

gene/protein mutant

APOE (isoform E4)

decreases_activity of

process

learning or memory

compared to apo E3 knock-in mice
Comment Mice that express human apo E4 develop 2.5-fold more amyloid deposits than do mice that express human apo E3.
Formal Description
Interaction-ID: 14529

gene/protein mutant

APOE (isoform E4)

increases_quantity of

phenotype

amyloid beta deposits

Comment In fibroblasts, human apoE3-containing HDLs from plasma form a complex with ABCA1, and lipid-free apo E inhibits formation of this complex. The apo E-ABCA1 interaction does not appear to depend on the isoform of apo E since apo E2, apo E3 and apo E4 bind to ABCA1 with similar affinity.
Formal Description
Interaction-ID: 14558

gene/protein mutant

APOE (isoform E4)

interacts (colocalizes) with

gene/protein

ABCA1

Drugbank entries Show/Hide entries for ABCA1