General Information:

Id: 1,893
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Vance JE and Hayashi H(2010) Formation and function of apolipoprotein E-containing lipoproteins in the nervous system Biochim. Biophys. Acta 1801: 806-818 [PMID: 20170744]

Interaction Information:

Comment Apo E has also been implicated in the deposition of amyloid plaques since apo E3, more readily than apo E4, forms a complex with Abeta peptides, and mediates the degradation of amyloid deposits.
Formal Description
Interaction-ID: 14493

gene/protein mutant

APOE (isoform E3)

decreases_quantity of

phenotype

amyloid beta deposits

Comment Individuals with one APOE4 isoform are 3 to 4 times as likely to develop AD as those without any APOE4, and people with two APOE4 alleles have a 12-fold higher risk of developing AD.
Formal Description
Interaction-ID: 14500

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Alzheimer disease

Comment Carriers of the APOE2 allele have decreased risk of developing AD.
Formal Description
Interaction-ID: 14501

gene/protein mutant

APOE (isoform E2)

decreases_activity of

disease

Alzheimer disease

Comment The APOE4 allele is also associated with an accelerated development and progression of several other neurodegenerative conditions such as Parkinson's disease, multiple sclerosis, head trauma, cerebral hemorrhage and possibly stroke.
Formal Description
Interaction-ID: 14502

gene/protein mutant

APOE (isoform E4)

increases_activity of

phenotype

neurodegeneration

Comment The APOE isoform E4 allele is also associated with an accelerated development and progression of several other neurodegenerative conditions such as Parkinson's disease, multiple sclerosis, head trauma, cerebral hemorrhage and possibly stroke.
Formal Description
Interaction-ID: 14513

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Parkinson disease

Comment The APOE4 allele is also associated with an accelerated development and progression of several other neurodegenerative conditions such as Parkinson's disease, multiple sclerosis, head trauma, cerebral hemorrhage and possibly stroke.
Formal Description
Interaction-ID: 14514

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Multiple sclerosis

Comment The expression of human APOE4, rather than human APOE3, in mice impaired synaptogenesis.
Formal Description
Interaction-ID: 14519

gene/protein mutant

APOE (isoform E4)

affects_activity of

process

synapse assembly

Comment Memory and learning were impaired in apo E4 knock-in mice compared to apo E3 knock-in mice.
Formal Description
Interaction-ID: 14521

gene/protein mutant

APOE (isoform E4)

decreases_activity of

process

learning or memory

compared to apo E3 knock-in mice
Comment Mice that express human apo E4 develop 2.5-fold more amyloid deposits than do mice that express human apo E3.
Formal Description
Interaction-ID: 14529

gene/protein mutant

APOE (isoform E4)

increases_quantity of

phenotype

amyloid beta deposits

Comment ApoJ/ CLU is another apolipoprotein that is abundant in the CNS and has been linked to AD.
Formal Description
Interaction-ID: 14548

gene/protein

CLU

affects_activity of

disease

Alzheimer disease

Comment ApoJ/ CLU has been reported to be a carrier of Abeta across the blood-brain barrier and to suppress Abeta deposition in the brain.
Formal Description
Interaction-ID: 14549

gene/protein

CLU

decreases_quantity of

gene/protein

Amyloid beta peptide

in brain
Comment The principal cells that secrete apoE in the CNS are astrocytes; microglia also secrete small amounts of apoE.
Formal Description
Interaction-ID: 14550

tissue/cell line

astrocyte

increases_quantity of

gene/protein

APOE

in CNS; via secretion
Drugbank entries Show/Hide entries for APOE
Comment The principal cells that secrete apoE in the CNS are astrocytes; microglia also secrete small amounts of apoE.
Formal Description
Interaction-ID: 14552

tissue/cell line

microglia

increases_quantity of

gene/protein

APOE

in CNS; via secretion
Drugbank entries Show/Hide entries for APOE
Comment In fibroblasts, human apo E3-containing HDLs from plasma form a complex with ABCA1, and lipid-free apo E inhibits formation of this complex.
Formal Description
Interaction-ID: 14555

gene/protein mutant

APOE (isoform E3)

interacts (colocalizes) with

complex/PPI

HDL

in human fibroblasts
Comment In fibroblasts, human apoE3-containing HDLs from plasma form a complex with ABCA1, and lipid-free apoE inhibits formation of this complex. The apo E-ABCA1 interaction does not appear to depend on the isoform of apo E since apo E2, apo E3 and apo E4 bind to ABCA1 with similar affinity.
Formal Description
Interaction-ID: 14557

gene/protein mutant

APOE (isoform E3)

interacts (colocalizes) with

gene/protein

ABCA1

Drugbank entries Show/Hide entries for ABCA1
Comment In fibroblasts, human apoE3-containing HDLs from plasma form a complex with ABCA1, and lipid-free apo E inhibits formation of this complex. The apo E-ABCA1 interaction does not appear to depend on the isoform of apo E since apo E2, apo E3 and apo E4 bind to ABCA1 with similar affinity.
Formal Description
Interaction-ID: 14558

gene/protein mutant

APOE (isoform E4)

interacts (colocalizes) with

gene/protein

ABCA1

Drugbank entries Show/Hide entries for ABCA1
Comment In fibroblasts, human apoE3-containing HDLs from plasma form a complex with ABCA1, and lipid-free apoE inhibits formation of this complex. The apo E-ABCA1 interaction does not appear to depend on the isoform of apo E since apo E2, apo E3 and apo E4 bind to ABCA1 with similar affinity.
Formal Description
Interaction-ID: 14559

gene/protein mutant

APOE (isoform E2)

interacts (colocalizes) with

gene/protein

ABCA1

Drugbank entries Show/Hide entries for ABCA1
Comment The importance of ABCA1 for the lipidation of apo E in the brain is underscored by experiments performed in ABCA1 knock-out mice.
Formal Description
Interaction-ID: 14563

gene/protein

ABCA1

increases_activity of

process

APOE lipidation

in mouse brain
Drugbank entries Show/Hide entries for ABCA1
Comment ABCG4, are highly expressed in astrocytes and neurons.
Formal Description
Interaction-ID: 14565

gene/protein

ABCG4

is_expressed_in

tissue/cell line

astrocyte

Comment ABCG4, are highly expressed in astrocytes and neurons.
Formal Description
Interaction-ID: 14567

gene/protein

ABCG4

is_expressed_in

tissue/cell line

neuron

Comment ABCG4 is also highly expressed in microglia, particularly in AD brains.
Formal Description
Interaction-ID: 14568

gene/protein

ABCG4

is_expressed_in

tissue/cell line

microglia

in AD brain
Comment ABCG4 is highly expressed in microglia, particularly in AD brains.
Formal Description
Interaction-ID: 14573

gene/protein

ABCG4

affects_activity of

disease

Alzheimer disease

Comment The importance of ABCA1 for the lipidation of apo E in the brain is underscored by experiments performed in ABCA1 knock-out mice.
Formal Description
Interaction-ID: 14575

process

protein lipidation

affects_activity of

gene/protein

APOE

Drugbank entries Show/Hide entries for APOE
Comment The expression of ABCA1 and ABCG1 in macrophages and fibroblasts is markedly increased by activation of the transcription factor LXR (liver X receptor).
Formal Description
Interaction-ID: 14578

gene/protein

ABCA1

is_expressed_in

tissue/cell line

macrophage

Drugbank entries Show/Hide entries for ABCA1
Comment The expression of ABCA1 and ABCG1 in macrophages and fibroblasts is markedly increased by activation of the transcription factor LXR (liver X receptor).
Formal Description
Interaction-ID: 14579

gene/protein

ABCA1

is_expressed_in

tissue/cell line

fibroblast

Drugbank entries Show/Hide entries for ABCA1
Comment The expression of ABCA1 and ABCG1 in macrophages and fibroblasts is markedly increased by activation of the transcription factor LXR (liver X receptor).
Formal Description
Interaction-ID: 14580

gene/protein

ABCG1

is_expressed_in

tissue/cell line

macrophage

Drugbank entries Show/Hide entries for ABCG1
Comment The expression of ABCA1 and ABCG1 in macrophages and fibroblasts is markedly increased by activation of the transcription factor LXR (liver X receptor).
Formal Description
Interaction-ID: 14581

gene/protein

ABCG1

is_expressed_in

tissue/cell line

fibroblast

Drugbank entries Show/Hide entries for ABCG1
Comment Apo E has been co-localized with amyloid deposits in plaques and also in neurofibrillary tangles in the brains of AD patients.
Formal Description
Interaction-ID: 14585

gene/protein

APOE

interacts (colocalizes) with

phenotype

neurofibrillary tangles

in AD patients
Drugbank entries Show/Hide entries for APOE
Comment The expression of ABCA1 and ABCG1 in macrophages and fibroblasts is markedly increased by activation of the transcription factor LXR (liver X receptor).
Formal Description
Interaction-ID: 46752

gene/protein

NR1H

increases_expression of

gene/protein

ABCA1

in macrophage and fibroblast
Drugbank entries Show/Hide entries for ABCA1
Comment The expression of ABCA1 and ABCG1 in macrophages and fibroblasts is markedly increased by activation of the transcription factor LXR (liver X receptor).
Formal Description
Interaction-ID: 46754

gene/protein

NR1H

increases_expression of

gene/protein

ABCG1

in macrophage and fibroblast
Drugbank entries Show/Hide entries for ABCG1
Comment The importance of ABCA1 for the lipidation of apo E in the brain is underscored by experiments performed in ABCA1 knock-out mice.
Formal Description
Interaction-ID: 129151

process

APOE lipidation

affects_activity of

gene/protein

APOE

Drugbank entries Show/Hide entries for APOE