General Information:
Id: | 1,885 |
Diseases: |
Status epilepticus
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Rattus norvegicus | |
article | |
Reference: | Chuang YC et al.(2009) Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus Epilepsia 50: 731-746 [PMID: 19178557] |
Interaction Information:
Comment | The kainate-induced seuzires promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7). |
Formal Description Interaction-ID: 14308 |
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Comment | The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7). |
Formal Description Interaction-ID: 14312 |
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Comment | The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7). |
Formal Description Interaction-ID: 14313 |
phenotype decreases_activity of complex/PPI Mitochondrial respiratory chain complex I |
Comment | The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7). |
Formal Description Interaction-ID: 14314 |
phenotype increases_activity of |
Comment | The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7). |
Formal Description Interaction-ID: 14316 |
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Drugbank entries | Show/Hide entries for CASP3 |
Comment | The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7). |
Formal Description Interaction-ID: 14317 |
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Comment | The kainate-induced seizures leads to excessive production of NOS II-derived NO, accompanied by increase in O2- production ans peroxynitrite formation. |
Formal Description Interaction-ID: 14319 |
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Drugbank entries | Show/Hide entries for NOS2 |
Comment | The kainate-induced seizures leads to excessive production of NOS II-derived NO, accompanied by increase in O2- production ans peroxynitrite formation. |
Formal Description Interaction-ID: 14322 |
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Drugbank entries | Show/Hide entries for NOS2 |
Comment | The kainate-induced seizures leads to excessive production of NOS II-derived NO, accompanied by increase in O2- production ans peroxynitrite formation. |
Formal Description Interaction-ID: 14323 |
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Drugbank entries | Show/Hide entries for NOS2 |