General Information:

Id: 1,885
Diseases: Status epilepticus
Rattus norvegicus
article
Reference: Chuang YC et al.(2009) Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus Epilepsia 50: 731-746 [PMID: 19178557]

Interaction Information:

Comment The kainate-induced seuzires promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7).
Formal Description
Interaction-ID: 14308

increases_quantity of

drug/chemical compound

O2-

Comment The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7).
Formal Description
Interaction-ID: 14312

increases_quantity of

drug/chemical compound

Peroxynitrite

Comment The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7).
Formal Description
Interaction-ID: 14313

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

Comment The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7).
Formal Description
Interaction-ID: 14314

increases_activity of

Comment The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7).
Formal Description
Interaction-ID: 14316

increases_activity of

gene/protein

CASP3

Drugbank entries Show/Hide entries for CASP3
Comment The kainate-induced seizures promote increase in O(2)(-) and peroxynitrite levels (3 to 24 h), depressed mitochondrial Complex I activity (3 h), enhanced translocation of cytochrome c to cytosol (day 1), and augmented activated caspase-3 (day 7) and DNA fragmentation (day 7).
Formal Description
Interaction-ID: 14317

increases_activity of

Comment The kainate-induced seizures leads to excessive production of NOS II-derived NO, accompanied by increase in O2- production ans peroxynitrite formation.
Formal Description
Interaction-ID: 14319

increases_quantity of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2
Comment The kainate-induced seizures leads to excessive production of NOS II-derived NO, accompanied by increase in O2- production ans peroxynitrite formation.
Formal Description
Interaction-ID: 14322

gene/protein

NOS2

increases_quantity of

drug/chemical compound

NO

Drugbank entries Show/Hide entries for NOS2
Comment The kainate-induced seizures leads to excessive production of NOS II-derived NO, accompanied by increase in O2- production ans peroxynitrite formation.
Formal Description
Interaction-ID: 14323

gene/protein

NOS2

increases_quantity of

drug/chemical compound

NO

Drugbank entries Show/Hide entries for NOS2