CIDeRplusGeneral Information:
| Id: | 1,832 |
| Diseases: |
Epilepsy, temporal lobe
Status epilepticus |
| Rattus norvegicus | |
| article | |
| Reference: | Waldbaum S et al.(2010) Persistent impairment of mitochondrial and tissue redox status during lithium-pilocarpine-induced epileptogenesis J. Neurochem. 115: 1172-1182 [PMID: 21219330] |
Interaction Information:
| Comment | The treatment by pilocarpine leads to the convulsive seizures of Sprague-Dawley rat. |
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Formal Description Interaction-ID: 13845 |
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| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | After lithium-pilocarpine treatment of hippocampus and neocortex the time-dependent increase in mitochondrial hydrogen peroxide (H2O2) production coincident with increased mtDNA lesion frequency. |
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Formal Description Interaction-ID: 13866 |
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| Comment | Acute increases (24-48 h) in H2O2 produc tion and mtDNA lesion frequency were dependent on the severity of convulsive seizure activity during initial status epilepticus. |
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Formal Description Interaction-ID: 13867 |
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| Comment | Tissue levels of GSH, GSH/GSSG, coenzyme A (CoASH), and CoASH/CoASSG were persistently impaired at all measured time points throughout epileptogenesis, that is, acutely (24-48 h), during the latent period (48 h to 7 days), and chronic epilepsy (21 days to 3 months. |
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Formal Description Interaction-ID: 13868 |
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| Drugbank entries | Show/Hide entries for |
| Comment | Tissue levels of GSH, GSH/GSSG, coenzyme A (CoASH), and CoASH/CoASSG were persistently impaired at all measured time points throughout epileptogenesis, that is, acutely (24-48 h), during the latent period (48 h to 7 days), and chronic epilepsy (21 days to 3 months). |
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Formal Description Interaction-ID: 13869 |
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| Comment | Tissue levels of GSH, GSH/GSSG, coenzyme A (CoASH), and CoASH/CoASSG were persistently impaired at all measured time points throughout epileptogenesis, that is, acutely (24-48 h), during the latent period (48 h to 7 days), and chronic epilepsy (21 days to 3 months). |
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Formal Description Interaction-ID: 13870 |
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| Comment | Tissue levels of GSH, GSH/GSSG, coenzyme A (CoASH), and CoASH/CoASSG were persistently impaired at all measured time points throughout epileptogenesis, that is, acutely (24-48 h), during the latent period (48 h to 7 days), and chronic epilepsy (21 days to 3 months). |
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Formal Description Interaction-ID: 13871 |
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| Comment | After lithium-pilocarpine treatment of hippocampus and neocortex the time-dependent increase in mitochondrial hydrogen peroxide (H2O2) production coincident with increased mtDNA lesion frequency. |
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Formal Description Interaction-ID: 13873 |
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