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Field	Query

	Field	Term

General Information:

Id:	1,823
Diseases:	Alzheimer disease - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000258 choroid plexus
Publication type:	article
Reference:	Vargas T et al.(2010) Abeta accumulation in choroid plexus is associated with mitochondrial-induced apoptosis Neurobiol. Aging 31: 1569-1581 [PMID: 18838197]

Interaction Information:

Comment	Alzheimer patients have an elevated expression of Abeta in the choroid plexus (CP), where it could impair the physiological functions of CP epithelium.
Formal Description Interaction-ID: 13691	disease Alzheimer disease increases_quantity of gene/protein Amyloid beta peptide (42) in AD choroid plexus

Comment	A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description Interaction-ID: 13695	gene/protein Amyloid beta peptide affects_quantity of drug/chemical compound NO in AD choroid plexus; when elevated expression of Abeta

Comment	A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description Interaction-ID: 13700	drug/chemical compound NO affects_activity of phenotype abnormal mitochondrial physiology

Comment	A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description Interaction-ID: 13701	phenotype abnormal mitochondrial physiology increases_activity of gene/protein MMP9

Comment	A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description Interaction-ID: 13702	gene/protein MMP9 affects_activity of process cell death

Comment	The presence of Abeta accumulation in CP of AD brains is associated with transcytosis impairmen.
Formal Description Interaction-ID: 13704	gene/protein Amyloid beta peptide increases_activity of phenotype transcytosis impairment when Abeta is accumulated in CP of AD brains

Comment	MMP-9 is increased in CP from AD subjects and APP/PS1 mice.
Formal Description Interaction-ID: 13806	disease Alzheimer disease increases_quantity of gene/protein MMP9 in choroid plexus

Comment	MMP-9 is increased in CP from AD subjects and APP/PS1 mice.
Formal Description Interaction-ID: 13807	organism model APP/PS1 mouse increases_quantity of gene/protein MMP9 in choroid plexus

Comment	Abeta (1-42) is associated with hydrogen peroxide levels in choroid plexus epithelial cell.
Formal Description Interaction-ID: 13808	gene/protein Amyloid beta peptide (42) affects_quantity of drug/chemical compound H2O2 in choroid plexus epithelial cells

Comment	NO production is increased in choroid plexus of AD subjects and APP/PS1 mice.
Formal Description Interaction-ID: 13809	disease Alzheimer disease increases_quantity of drug/chemical compound NO in choroid plexus

Comment	NO production is increased in choroid plexus of AD subjects and APP/PS1 mice.
Formal Description Interaction-ID: 13810	organism model APP/PS1 mouse increases_quantity of drug/chemical compound NO in choroid plexus

Comment	Mitochondrial damage is observed in choroid plexus of AD subjects and in vitro.
Formal Description Interaction-ID: 13811	disease Alzheimer disease increases_activity of process mitophagy in choroid plexus

Comment	Abeta (1-42) increases caspase 3 and 9 expression in CP epithelial cell.
Formal Description Interaction-ID: 13812	gene/protein Amyloid beta peptide (42) increases_expression of gene/protein CASP3 in choroid plexus epithelial cells
Drugbank entries	Show/Hide entries for CASP3
Drugbank DB01017	Minocycline negative modulator CASP3
Drugbank DB03124	5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbam ... not specified CASP3
Drugbank DB06862	2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)- ... not specified CASP3
Drugbank DB07696	methyl (3S)-3-[(tert-butoxycarbonyl)amin ... not specified CASP3
Drugbank DB08213	1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE- ... not specified CASP3
Drugbank DB08229	[N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL) ... not specified CASP3
Drugbank DB08251	4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL) ... not specified CASP3
Drugbank DB08497	(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2 ... not specified CASP3
Drugbank DB08498	(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4- ... not specified CASP3
Drugbank DB08499	N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-t ... not specified CASP3
Drugbank DB03124	5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbam ... not specified CASP3

Comment	Abeta (1-42) increases caspase 3 and 9 expression in CP epithelial cell.
Formal Description Interaction-ID: 13814	gene/protein Amyloid beta peptide (42) increases_expression of gene/protein CASP9 in choroid plexus epithelial cells

Comment	Cell death is increased in CP of AD subjects and APP/PS1 mice.
Formal Description Interaction-ID: 13815	disease Alzheimer disease increases_activity of process cell death in choroid plexus

Comment	Cell death is increased in CP of AD subjects and APP/PS1 mice.
Formal Description Interaction-ID: 13816	organism model APP/PS1 mouse increases_activity of process cell death in choroid plexus

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