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Field	Query

	Field	Term

General Information:

Id:	1,779
Diseases:	Alzheimer disease - [OMIM]
Organism:	Rattus norvegicus
Tissue/Cell line:	primary rat astrocyte cultures
Publication type:	article
Reference:	Padmashri R and Sikdar SK(2008) Glutamate transporter blockade affects Ca(2+) responses in astrocytes. Neuroscience 151: 56-62 [PMID: 18037246]

Interaction Information:

Comment	Glutamate transporter blockade attenuates Ca2+ responses in astrocytes.
Formal Description Interaction-ID: 13358	gene/protein Glutamate transmembrane transporter increases_activity of process response to calcium ion in astrocytes

Comment	Glutamate has a stimulatory effect of on the Ca2+ responses in cultured cortical astrocytes.
Formal Description Interaction-ID: 13361	drug/chemical compound Glutamate increases_activity of process response to calcium ion

Comment	Astrocytes release glutamate.
Formal Description Interaction-ID: 13362	tissue/cell line astrocyte affects_quantity of drug/chemical compound Glutamate

Comment	Elevated extracellular glutamate by glutamate transporter blockade can attenuate Ca2+ responses in astrocytes.
Formal Description Interaction-ID: 13363	gene/protein Glutamate transmembrane transporter affects_quantity of drug/chemical compound Glutamate

Comment	Elevated extracellular glutamate by glutamate transporter blockade can attenuate Ca2+ responses in astrocytes.
Formal Description Interaction-ID: 144742	gene/protein Glutamate transmembrane transporter increases_transport of drug/chemical compound Glutamate

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