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Field	Query

	Field	Term

General Information:

Id:	1,777
Diseases:	Alzheimer disease - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	cerebrospinal fluid concentration
Publication type:	article
Reference:	Kaiser E et al.(2010) Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimers disease. Neurodegener Dis 7: 251-259 [PMID: 20551690]

Interaction Information:

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13318	disease Alzheimer disease increases_quantity of drug/chemical compound Urea in CSF
Drugbank entries	Show/Hide entries for Urea
Drugbank DB02899	N-Carboxymethionine not specified ureA
Drugbank DB03904	Urea not specified ARG1
Drugbank DB03904	Urea not specified CA2
Drugbank DB03904	Urea not specified CTNNB1
Drugbank DB03904	Urea not specified yedY
Drugbank DB03904	Urea not specified ""
Drugbank DB03904	Urea not specified folA
Drugbank DB03904	Urea not specified ARG1
Drugbank DB03904	Urea not specified CA2
Drugbank DB03904	Urea not specified ""
Drugbank DB03904	Urea not specified CTNNB1
Drugbank DB03904	Urea not specified yedY
Drugbank DB03904	Urea not specified folA

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13320	disease Alzheimer disease increases_quantity of drug/chemical compound Threonine in CSF

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13323	disease Alzheimer disease increases_quantity of drug/chemical compound Glutamate in CSF

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13325	disease Alzheimer disease increases_quantity of drug/chemical compound Citrulline in CSF

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13329	disease Alzheimer disease increases_quantity of drug/chemical compound (S)-2-Aminobutanoate in CSF

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13332	disease Alzheimer disease increases_quantity of drug/chemical compound Ornithine in CSF

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13333	disease Alzheimer disease increases_quantity of drug/chemical compound NH3 in CSF

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13334	disease Alzheimer disease increases_quantity of drug/chemical compound Arginine in CSF

Comment	Urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine were localized and significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13335	drug/chemical compound Urea is localized in tissue/cell line cerebrospinal fluid
Drugbank entries	Show/Hide entries for Urea
Drugbank DB02899	N-Carboxymethionine not specified ureA
Drugbank DB03904	Urea not specified ARG1
Drugbank DB03904	Urea not specified CA2
Drugbank DB03904	Urea not specified CTNNB1
Drugbank DB03904	Urea not specified yedY
Drugbank DB03904	Urea not specified ""
Drugbank DB03904	Urea not specified folA
Drugbank DB03904	Urea not specified ARG1
Drugbank DB03904	Urea not specified CA2
Drugbank DB03904	Urea not specified ""
Drugbank DB03904	Urea not specified CTNNB1
Drugbank DB03904	Urea not specified yedY
Drugbank DB03904	Urea not specified folA

Comment	Urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine were localized and significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13336	drug/chemical compound Threonine is localized in tissue/cell line cerebrospinal fluid

Comment	Urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine were localized and significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13340	drug/chemical compound Glutamate is localized in tissue/cell line cerebrospinal fluid

Comment	Urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine were localized and significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13341	drug/chemical compound Citrulline is localized in tissue/cell line cerebrospinal fluid

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13342	drug/chemical compound (S)-2-Aminobutanoate is localized in tissue/cell line cerebrospinal fluid

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13344	drug/chemical compound Ornithine is localized in tissue/cell line cerebrospinal fluid

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13345	drug/chemical compound NH3 is localized in tissue/cell line cerebrospinal fluid

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 13346	drug/chemical compound Arginine is localized in tissue/cell line cerebrospinal fluid

Comment	8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI.
Formal Description Interaction-ID: 152574	disease Alzheimer disease increases_activity of phenotype increased circulating ammonia level in CSF

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