General Information:

Id: 1,699
Diseases: Schizophrenia - [OMIM]
Mammalia
review
Reference: Verge B et al.(2011) Mitochondrial DNA (mtDNA) and schizophrenia Eur. Psychiatry 26: 45-56 [PMID: 20980130]

Interaction Information:

Comment In postmortem brain tissue, the structural integrity of mitochondria in the striata of schizophrenic patients was not different from controls.
Formal Description
Interaction-ID: 12746

disease

Schizophrenia

NOT affects_quantity of

cellular component

mitochondrion

in striatum
Comment The caudate and putamen contained significantly fewer mitochondrial profiles, suggesting that these structures had decreased energy demands or a diminished capacity for energy generation.
Formal Description
Interaction-ID: 12747

disease

Schizophrenia

decreases_quantity of

cellular component

mitochondrion

in caudate and putamen
Comment A significant decrease in the volume density of mitochondria has been observed in oligodendroglial cells of the caudate nucleus and the prefrontal cortex of schizophrenia patients when compared to controls.
Formal Description
Interaction-ID: 12748

phenotype

decreased mitochondria number

affects_activity of

disease

Schizophrenia

in oligodendroglial cells of caudate nucleus and prefrontal cortex
Comment In the substantia nigra of four schizophrenic patients, presynaptic boutons specific to dopaminergic neurons showed hyperplasia of mitochondria,among other ultrastructural changes compared to three control subjects.
Formal Description
Interaction-ID: 12972

disease

Schizophrenia

affects_activity of

process

mitochondrion morphogenesis

in dopaminergic neurons of substantia nigra
Comment The structural abnormalities observed in the mitochondria of schizophrenia patients may be related to medication by antipsychotics such as risperidone, quetiapine, andolanzapine. All these anitipsychotics inhibit activity of mitotochondrial respiratory chain complex I.
Formal Description
Interaction-ID: 12973

drug/chemical compound

Risperidone

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

Drugbank entries Show/Hide entries for Risperidone
Comment The structural abnormalities observed in the mitochondria of schizophrenia patients may be related to medication by antipsychotics such as risperidone, quetiapine, andolanzapine. All these anitipsychotics inhibit activity of mitotochondrial respiratory chain complex I.
Formal Description
Interaction-ID: 12977

drug/chemical compound

Quetiapine

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

Drugbank entries Show/Hide entries for Quetiapine
Comment The structural abnormalities observed in the mitochondria of schizophrenia patients may be related to medication by antipsychotics such as risperidone, quetiapine, and olanzapine. All these anitipsychotics inhibit activity of mitotochondrial respiratory chain complex I.
Formal Description
Interaction-ID: 12979

drug/chemical compound

Olanzapine

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

Drugbank entries Show/Hide entries for Olanzapine
Comment There was no observe differences between schizophrenia patients and controls with regard to ATP or other high-energy phosphates, such as phosphocreatine or inorganic phosphate in the prefrontal cortex.
Formal Description
Interaction-ID: 12986

disease

Schizophrenia

NOT affects_quantity of

drug/chemical compound

ATP

in prefrontal cortex
Comment There was no observe differences between schizophrenia patients and controls with regard to ATP or other high-energy phosphates, such as phosphocreatine or inorganic phosphate in the prefrontal cortex.
Formal Description
Interaction-ID: 12987

disease

Schizophrenia

NOT affects_quantity of

drug/chemical compound

Phosphocreatine

in prefrontal cortex
Comment There was no observe differences between schizophrenia patients and controls with regard to ATP or other high-energy phosphates, such as phosphocreatine or inorganic phosphate in the prefrontal cortex.
Formal Description
Interaction-ID: 12988

disease

Schizophrenia

NOT affects_quantity of

drug/chemical compound

PO4

in prefrontal cortex
Comment Complex I activity measured in mitochondria isolated from platelets significantly increased in schizophrenia patients with acute psychosis, regardless of whether they were medicated, compared to controls.
Formal Description
Interaction-ID: 12989

disease

Schizophrenia

increases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in mitochondria of plateles
Comment Interestingly, in both patients and controls, this activity was significantly reduced when dopamine is added to the platelets; however, in the reduction of mitochondria of schizophrenia patients is twice that of controls.
Formal Description
Interaction-ID: 12990

drug/chemical compound

Dopamine

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in mitochondria of plateles
Drugbank entries Show/Hide entries for Dopamine
Comment In postmortem brain specimens, a reduction in complex I and III activity in the temporal cortex and basal ganglia has been observed, whereas complex IV activity was reduced in the frontal and temporal cortices.
Formal Description
Interaction-ID: 13032

disease

Schizophrenia

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in the temporal cortex and basal ganglia
Comment In postmortem brain specimens, a reduction in complex I and III activity in the temporal cortex and basal ganglia has been observed, whereas complex IV activity was reduced in the frontal and temporal cortices.
Formal Description
Interaction-ID: 13033

disease

Schizophrenia

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex III

in the temporal cortex and basal ganglia
Comment In postmortem brain specimens, a reduction in complex I and III activity in the temporal cortex and basal ganglia has been observed, whereas complex IV activity was reduced in the frontal and temporal cortices.
Formal Description
Interaction-ID: 13034

disease

Schizophrenia

increases_activity of

complex/PPI

Mitochondrial respiratory chain complex IV

n the frontal and temporal cortices
Comment Another study revealed that complex IV activity decreased in the caudate nucleus but increased in putamen and nucleus accumbens; complex II activity increased in putamen and nucleus accumbens; and there were not differences in complex I.
Formal Description
Interaction-ID: 13035

disease

Schizophrenia

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex IV

in the caudate nucleus
Comment Another study revealed that complex IV activity decreased in the caudate nucleus but increased in putamen and nucleus accumbens; complex II activity increased in putamen and nucleus accumbens; and there were not differences in complex I.
Formal Description
Interaction-ID: 13036

disease

Schizophrenia

increases_activity of

complex/PPI

Mitochondrial respiratory chain complex IV

in putamen and nucleus accumbens
Comment Another study revealed that complex IV activity decreased in the caudate nucleus but increased in putamen and nucleus accumbens; complex II activity increased in putamen and nucleus accumbens; and there were not differences in complex I.
Formal Description
Interaction-ID: 13038

disease

Schizophrenia

increases_activity of

complex/PPI

Mitochondrial respiratory chain complex II

in putamen and nucleus accumbens
Comment Another study revealed that complex IV activity decreased in the caudate nucleus but increased in putamen and nucleus accumbens; complex II activity increased in putamen and nucleus accumbens; and there were not differences in complex I.
Formal Description
Interaction-ID: 13039

disease

Schizophrenia

NOT affects_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in putamen and nucleus accumbens