General Information:

Id: 1,680
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
APPsw PC12 cell
article
Reference: Keil U et al.(2004) Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure Pol J Pharmacol 56: 631-634 [PMID: 15591653]

Interaction Information:

Comment APPsw PC12 cells showed increased NO levels, decreased cytochrome C oxidase activity and reduced ATP levels compared to wild-type APP bearing cells.
Formal Description
Interaction-ID: 12547

tissue/cell line

PC-12 cell

increases_quantity of

drug/chemical compound

NO

Comment APPsw PC12 cells showed increased NO levels, decreased cytochrome C oxidase activity and reduced ATP levels compared to wild-type APP bearing cells.
Formal Description
Interaction-ID: 12550

tissue/cell line

PC-12 cell

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex IV

Comment APPsw PC12 cells showed increased NO levels, decreased cytochrome C oxidase activity and reduced ATP levels compared to wild-type APP bearing cells.
Formal Description
Interaction-ID: 12551

tissue/cell line

PC-12 cell

decreases_quantity of

drug/chemical compound

ATP

Comment Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure.
Formal Description
Interaction-ID: 12552

drug/chemical compound

NO

affects_activity of

cellular component

mitochondrion

Comment The involvement of nitric oxide (NO) has been implicated in the pathogenesis of AD.
Formal Description
Interaction-ID: 12558

drug/chemical compound

NO

affects_activity of

disease

Alzheimer disease