General Information:

Id: 1,598
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0003292 RAW-264.7 cell
article
Reference: Hong Byun E et al.(2010) TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor J. Immunol. 185: 33-45 [PMID: 20511545]

Interaction Information:

Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11649

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

TNF

in peritoneal macrophages
Drugbank entries Show/Hide entries for TNF
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11665

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

IL6

in peritoneal macrophages
Drugbank entries Show/Hide entries for IL6
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11666

drug/chemical compound

Lipopolysaccharide

increases_quantity of

drug/chemical compound

NO

in peritoneal macrophages
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11667

drug/chemical compound

Lipopolysaccharide

increases_activity of

process

inflammatory response

in peritoneal macrophages
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11668

drug/chemical compound

Epigallocatechin 3-gallate

decreases_activity of

process

inflammatory response

in peritoneal macrophages; after LPS treatment
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11669

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

TNF

in peritoneal macrophages; after LPS treatment
Drugbank entries Show/Hide entries for TNF
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11670

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

IL6

in peritoneal macrophages; after LPS treatment
Drugbank entries Show/Hide entries for IL6
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11671

drug/chemical compound

Epigallocatechin 3-gallate

decreases_quantity of

drug/chemical compound

NO

in peritoneal macrophages; after LPS treatment
Comment Anti-67LR Ab treatment or RNA interference-mediated silencing of 67LR resulted in abrogation of the inhibitory action of EGCG on LPS-induced production of inflammatory mediators.
Formal Description
Interaction-ID: 11672

gene/protein

RPSA

increases_activity of

drug/chemical compound

Epigallocatechin 3-gallate

in peritoneal macrophages
Comment The expression of TLR4, CD14, and MyD88 in 67LR-downregulated cells was not altered compared to control cells.
Formal Description
Interaction-ID: 11684

gene/protein

RPSA

NOT affects_expression of

gene/protein

TLR4

in macrophages
Drugbank entries Show/Hide entries for TLR4
Comment The expression of TLR4, CD14, and MyD88 in 67LR-downregulated cells was not altered compared to control cells.
Formal Description
Interaction-ID: 11686

gene/protein

RPSA

NOT affects_expression of

gene/protein

CD14

in macrophages
Comment The expression of TLR4, CD14, and MyD88 in 67LR-downregulated cells was not altered compared to control cells.
Formal Description
Interaction-ID: 11687

gene/protein

RPSA

NOT affects_expression of

gene/protein

MYD88

in macrophages
Comment EGCG reduced the TLR4 expression through 67LR.
Formal Description
Interaction-ID: 11689

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

TLR4

via RPSA
Drugbank entries Show/Hide entries for TLR4
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11699

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

CSF2

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11700

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

GBP1

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11701

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

IFI202b

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11702

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

REL

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11703

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

IFI47

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11704

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

CPT1B

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11705

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

RELB

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11706

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

STAT1

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11707

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

ISG15

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11708

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

CCL5

in macrophages
Drugbank entries Show/Hide entries for CCL5
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11709

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

CXCL2

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11710

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

IL1A

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11711

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

TAP1

in macrophages
Drugbank entries Show/Hide entries for TAP1
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11712

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

GBP3

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11717

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

IL1R1

in macrophages
Drugbank entries Show/Hide entries for IL1R1
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11718

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

TRAF1

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11719

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

CCL7

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11720

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

CSF3

in macrophages
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11721

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

PTGS2

in macrophages
Drugbank entries Show/Hide entries for PTGS2
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11723

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

IL6

in macrophages
Drugbank entries Show/Hide entries for IL6
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11724

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

IL1B

in macrophages
Drugbank entries Show/Hide entries for IL1B
Comment LPS induced the expression of the inflammatory-related genes colony-stimulating factor 2, Gbp1, Ifi202b, Rel, Ifi47, Mcpt1, Relb, Stat1, Isg15, Ccl5/RANTES, Cxcl2, IL-1alpha, Tap1, Gbp3, Il1r1, Traf1, Ccl7, Csf3, Ptgs2, IL-6, and IL-1beta and EGCG suppressed this induction via 67LR.
Formal Description
Interaction-ID: 11725

drug/chemical compound

Epigallocatechin 3-gallate

decreases_activity of

drug/chemical compound

Lipopolysaccharide

in macrophages; via RPSA
Comment EGCG inhibits the MAPK pathway through 67LR.
Formal Description
Interaction-ID: 11726

drug/chemical compound

Epigallocatechin 3-gallate

decreases_activity of

process

stress-activated MAPK cascade

in macrophages; via RPSA
Comment EGCG inhibits LPS-induced NF-kappaB activation through 67LR.
Formal Description
Interaction-ID: 11727

drug/chemical compound

Epigallocatechin 3-gallate

decreases_activity of

complex/PPI

NF-kappaB complex

in macrophages; after LPS activation via RPSA
Comment EGCG reduced the TLR4 expression through 67LR.
Formal Description
Interaction-ID: 11777

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

TLR4

in macrophages; via RPSA
Drugbank entries Show/Hide entries for TLR4
Comment EGCG induced a rapid upregulation of Toll-interacting protein (Tollip), a negative regulator of TLR signaling, and this EGCG action was prevented by 67LR silencing or anti-67LR Ab treatment.
Formal Description
Interaction-ID: 11778

drug/chemical compound

Epigallocatechin 3-gallate

increases_expression of

gene/protein

TOLLIP

in macrophages; via RPSA
Comment EGCG induced a rapid upregulation of Toll-interacting protein (Tollip), a negative regulator of TLR signaling, and this EGCG action was prevented by 67LR silencing or anti-67LR Ab treatment.
Formal Description
Interaction-ID: 11779

drug/chemical compound

Epigallocatechin 3-gallate

decreases_activity of

process

toll-like receptor 4 signaling pathway

in macrophages; via RPSA
Comment EGCG induced a rapid upregulation of Toll-interacting protein (Tollip), a negative regulator of TLR signaling, and this EGCG action was prevented by 67LR silencing or anti-67LR Ab treatment.
Formal Description
Interaction-ID: 11780

gene/protein

TOLLIP

decreases_activity of

process

toll-like receptor 4 signaling pathway

in macrophages