General Information:

Id: 15,346 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: [PMID: 32397599]

Interaction Information:

Comment Some mood stabilizers, such as verapamil, loperamide, clonidine, and calpastatin, induce the degradation of aggregate-prone proteins by the autophagy-lysosome system via a reduction in inositol phosphate 3 (IP3) levels, which inhibits the autophagosome formation step. In the phosphoinositol cycle, lithium inhibits inositol monophosphatase (IMPase), whereas carbamazepine and valproic acid inhibit inositol synthesis.
Formal Description
Interaction-ID: 145095

drug/chemical compound

Valproic acid

decreases_activity of

process

inositol biosynthetic process

Drugbank entries Show/Hide entries for Valproic acid