General Information:

Id: 1,532
Diseases: Parkinson disease
Mammalia
BTO:0001009 PC-12 cell, rat; LUHMES cells, human dopaminergic cells
article
Reference: Johansen JL et al.(2010) HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells J. Neurochem. 115: 209-219 [PMID: 20649842]

Interaction Information:

Comment HPH inhibitors and hypoxia induce HIF-1 downstream genes in PC12 cells.
Formal Description
Interaction-ID: 10918

process

response to hypoxia

increases_activity of

gene/protein

HIF1A

Drugbank entries Show/Hide entries for HIF1A
Comment HPH inhibitors and hypoxia induce HIF-1 downstream genes in PC12 cells.
Formal Description
Interaction-ID: 10919

gene/protein

HPH

decreases_activity of

gene/protein

HIF1A

Drugbank entries Show/Hide entries for HIF1A
Comment HPH inhibitors and hypoxia induce HIF-1 downstream genes in PC12 cells.
Formal Description
Interaction-ID: 10920

process

response to hypoxia

decreases_activity of

gene/protein

HPH

Comment HPH inhibitors like FG41, and hypoxia induce HIF-1 downstream genes in PC12 cells.
Formal Description
Interaction-ID: 10921

drug/chemical compound

FG-0041

decreases_activity of

gene/protein

HPH

Comment FG41 increases cell viability in PC12 and LUHMES cells and preserves mitochondrial membrane potential.
Formal Description
Interaction-ID: 10922

drug/chemical compound

FG-0041

decreases_activity of

process

neuron death

by increasing HIF1 activity
Comment FG41 increases cell viability in PC12 and LUHMES cells and preserves mitochondrial membrane potential.
Formal Description
Interaction-ID: 10923

drug/chemical compound

FG-0041

decreases_activity of

process

mitochondrial depolarization

Comment FG41 enhances dopamine release in PC12 cells and in primary dopaminergic cultures.
Formal Description
Interaction-ID: 10924

drug/chemical compound

FG-0041

increases_quantity of

drug/chemical compound

Dopamine

Drugbank entries Show/Hide entries for
Comment FG41 enhances dopamine release in PC12 cells and in primary dopaminergic cultures.
Formal Description
Interaction-ID: 10925

drug/chemical compound

FG-0041

increases_activity of

process

dopamine secretion

Comment Knockdown of HPHs up-regulates TH- and HIF-activity and dopamine release in PC12 cells and in primary dopaminergic cultures.
Formal Description
Interaction-ID: 10926

gene/protein

HPH

decreases_activity of

gene/protein

TH

via inhibition of HIF1
Drugbank entries Show/Hide entries for TH
Comment Knockdown of HPHs up-regulates TH- and HIF-activity and dopamine release in PC12 cells and in primary dopaminergic cultures.
Formal Description
Interaction-ID: 10927

gene/protein

HPH

decreases_activity of

process

dopamine secretion

via inhibition of TH