General Information:

Id: 1,531
Diseases: Parkinson disease
Mammalia
article/cited
Reference: Johansen JL et al.(2010) HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells J. Neurochem. 115: 209-219 [PMID: 20649842]

Interaction Information:

Comment Hypoxia inducible transcription factor has neuroprotective properties. (cited information)
Formal Description
Interaction-ID: 10914

gene/protein

HIF1A

decreases_activity of

process

neuron death

Drugbank entries Show/Hide entries for HIF1A
Comment Hypoxia induces tyrosine hydroxylase expression in substantia nigra, which is the rate-limiting enzyme in dopamine synthesis. (cited information)
Formal Description
Interaction-ID: 10915

process

response to hypoxia

increases_expression of

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Hypoxia induces tyrosine hydroxylase expression in substantia nigra, which is the rate-limiting enzyme in dopamine synthesis, resulting in elevated dopamine release. (cited information)
Formal Description
Interaction-ID: 10916

gene/protein

TH

increases_quantity of

drug/chemical compound

Dopamine

Drugbank entries Show/Hide entries for TH or Dopamine
Comment Hypoxia induces tyrosine hydroxylase expression in substantia nigra, which is the rate-limiting enzyme in dopamine synthesis. (cited information)
Formal Description
Interaction-ID: 10917

gene/protein

TH

increases_activity of

process

dopamine biosynthetic process

Drugbank entries Show/Hide entries for TH
Comment Hypoxia induces tyrosine hydroxylase expression in substantia nigra, which is the rate-limiting enzyme in dopamine synthesis, resulting in elevated dopamine release. (cited information)
Formal Description
Interaction-ID: 10928

gene/protein

TH

increases_activity of

process

dopamine secretion

Drugbank entries Show/Hide entries for TH