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Field	Query

	Field	Term

General Information:

Id:	14,381
Diseases:	Metabolic
Organism:	Rattus norvegicus
Tissue/Cell line:	rat brain; rat pancreas
Publication type:	article/cited
Reference:	Dirkx R Jr et al.(1995) Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase J Biol Chem 270: 2241-2246 [PMID: 7836456]

Interaction Information:

Comment	The two isoforms of glutamic acid decarboxylase (GAD), GAD67 and GAD65, synthesize the neurotransmitter gamma-aminobutyric acid in neurons and pancreatic beta-cells. (cited information)
Formal Description Interaction-ID: 135765	gene/protein GAD1 increases_quantity of drug/chemical compound GABA in neurons and pancreatic beta-cells
Drugbank entries	Show/Hide entries for GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00142	L-Glutamic Acid not specified GAD1
Drugbank DB00142	L-Glutamic Acid not specified GAD1

Comment	GAD67 interacts with the NH2-terminal region of GAD65. A pool of neuronal GAD67 co-localizes with GAD65 in the Golgi complex region and in many synapses. The NH2-terminal region of GAD65 is involved in membrane association as well as in binding to GAD67.
Formal Description Interaction-ID: 135766	gene/protein GAD1 interacts (colocalizes) with gene/protein GAD2
Drugbank entries	Show/Hide entries for GAD1 or GAD2
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00142	L-Glutamic Acid not specified GAD1
Drugbank DB00142	L-Glutamic Acid not specified GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD2
Drugbank DB00142	L-Glutamic Acid not specified GAD2
Drugbank DB00142	L-Glutamic Acid not specified GAD2

Comment	GAD67 interacts with the NH2-terminal region of GAD65. GAD65-GAD67 association occurs in vivo and is required for the targeting of GAD67 to membranes.
Formal Description Interaction-ID: 135768	complex/PPI GAD1-GAD2 interaction increases_activity of process GAD1 targeting to membrane in vivo

Comment	Because of the interaction of GAD67 with GAD65, also GAD67 is targeted to intracellular membrane compartments.
Formal Description Interaction-ID: 135769	complex/PPI GAD1-GAD2 interaction increases_activity of process GAD1 targeting to intracellular membrane compartments

Comment	The two isoforms of glutamic acid decarboxylase (GAD), GAD67 and GAD65, synthesize the neurotransmitter gamma-aminobutyric acid in neurons and pancreatic beta-cells. (cited information)
Formal Description Interaction-ID: 135770	gene/protein GAD2 increases_quantity of drug/chemical compound GABA in neurons and pancreatic beta-cells
Drugbank entries	Show/Hide entries for GAD2
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD2
Drugbank DB00142	L-Glutamic Acid not specified GAD2
Drugbank DB00142	L-Glutamic Acid not specified GAD2

Comment	GAD67 interacts with the NH2-terminal region of GAD65. A pool of neuronal GAD67 co-localizes with GAD65 in the Golgi complex region and in many synapses. in the perinuclear region of some pancreatic beta-cells.
Formal Description Interaction-ID: 135771	gene/protein GAD1 is_part_of complex/PPI GAD1-GAD2 interaction in the Golgi complex region and in many synapses, and in the perinuclear region of some pancreatic beta-cells
Drugbank entries	Show/Hide entries for GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD1
Drugbank DB00142	L-Glutamic Acid not specified GAD1
Drugbank DB00142	L-Glutamic Acid not specified GAD1

Comment	GAD67 interacts with the NH2-terminal region of GAD65. A pool of neuronal GAD67 co-localizes with GAD65 in the Golgi complex region and in many synapses. The two isoforms of glutamic acid decarboxylase (GAD), GAD67 and GAD65, co-localize in the perinuclear region of some pancreatic beta-cells. The NH2-terminal region of GAD65 is involved in membrane association as well as in binding to GAD67.
Formal Description Interaction-ID: 135772	gene/protein GAD2 is_part_of complex/PPI GAD1-GAD2 interaction in the Golgi complex region and in many synapses, and in the perinuclear region of some pancreatic beta-cells
Drugbank entries	Show/Hide entries for GAD2
Drugbank DB00114	Pyridoxal Phosphate cofactor GAD2
Drugbank DB00142	L-Glutamic Acid not specified GAD2
Drugbank DB00142	L-Glutamic Acid not specified GAD2

Comment	GAD67 interacts with the NH2-terminal region of GAD65. GAD65-GAD67 association occurs in vivo and is required for the targeting of GAD67 to membranes.
Formal Description Interaction-ID: 135773	complex/PPI GAD1-GAD2 interaction increases_activity of process protein targeting to membrane in vivo; concerning GAD67 targeting to membrane

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