CIDeRplusGeneral Information:
| Id: | 14,195 (click here to show other Interactions for entry) |
| Diseases: |
Neurodegenerative disorder
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| Rattus norvegicus | |
| article | |
| Reference: | Stragier B et al.(2005) In vivo characterization of the angiotensin-(1-7)-induced dopamine and gamma-aminobutyric acid release in the striatum of the rat Eur J Neurosci 22: 658-664 [PMID: 16101747] |
Interaction Information:
| Comment | The effect of angiotensin (Ang)-1-7 on dopamine, gamma-aminobutyric acid (GABA) and glutamate release in the striatum of the rat was examined using in vivo microdialysis. Ang-(1-7) was administered locally in the striatum through the microdialysis probe. At a concentration of 100 microm, Ang-(1-7) caused a significant increase in extracellular dopamine and GABA but had no effect on glutamate release. EC33, an inhibitor of aminopeptidase A, had no effect on the Ang-(1-7)-induced GABA increase but the GABA release was blocked by the putative AT(1-7) receptor antagonist A779 (0.1 microm) and by the nitric oxide synthase inhibitor L-NAME (1 mm). These drugs could not block the effect of Ang-(1-7) on the striatal dopamine release suggesting that only the observed effects on GABA release are mediated by the AT(1-7) receptor and/or are associated with a release of nitric oxide. |
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Formal Description Interaction-ID: 134039 |
gene/protein increases_quantity of drug/chemical compound |