General Information:

Id: 1,403
Diseases: Parkinson disease
Mus musculus
article
Reference: Taylor TN et al.(2009) Nonmotor symptoms of Parkinsons disease revealed in an animal model with reduced monoamine storage capacity J. Neurosci. 29: 8103-8113 [PMID: 19553450]

Interaction Information:

Comment Transgenic mice expressing low levels of VMAT2 develop Parkinson disease like symptoms.
Formal Description
Interaction-ID: 9726

gene/protein

SLC18A2

affects_activity of

disease

Parkinson disease

Drugbank entries Show/Hide entries for SLC18A2
Comment Mice with a 95% genetic reduction in vesicular monoamine transporter expression (VMAT2-deficient, VMAT2 LO) display progressive loss of striatal dopamine, L-DOPA-responsive motor deficits, alpha-synuclein accumulation, and nigral dopaminergic cell loss.
Formal Description
Interaction-ID: 9733

gene/protein

SLC18A2

affects_quantity of

drug/chemical compound

Dopamine

Drugbank entries Show/Hide entries for SLC18A2 or Dopamine
Comment Mice with a 95% genetic reduction in vesicular monoamine transporter expression (VMAT2-deficient, VMAT2 LO) display progressive loss of striatal dopamine, L-DOPA-responsive motor deficits, alpha-synuclein accumulation, and nigral dopaminergic cell loss.
Formal Description
Interaction-ID: 9734

gene/protein

SLC18A2

affects_quantity of

phenotype

alpha-synuclein inclusion body

Drugbank entries Show/Hide entries for SLC18A2