CIDeRplusGeneral Information:
| Id: | 13,967 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Lorenzo PI et al.The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences [PMID: 28282933] |
Interaction Information:
| Comment | PAX4 is mainly expressed in the endocrine pancreas where it plays an essential role in the generation of insulin-producing beta-cells during embryonic development and later on, during adulthood, is a beta-cell master regulator in adaptation processes. During pancreas development PAX4 is initially expressed in all endocrine progenitors, being thereafter implicated in the commitment of beta/delta progenitors and further development of beta-cells. The lack of this gene in mouse models leads to the near absence of beta- and delta-cells, coupled to an increase in the number of alpha-cells, rendering the animals severely hyperglycemic leading to neonatal death. Further evidence on PAX4 triggering beta-cell commitment arises from transgenic mouse models where induction of PAX4 expression in early pancreatic epithelium, or in endocrine committed precursor cells induces the formation of insulin producing beta-cells at the expense of all other islet cell phenotypes. |
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Formal Description Interaction-ID: 131981 |
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