General Information:

Id: 1,390
Diseases: Parkinson disease
Mammalia
article/cited
Reference: Wang J et al.(2009) 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria J. Biol. Chem. 284 [PMID: 19289463]

Interaction Information:

Comment 14-3-3 proteins have long been acknowledged to stimulate the activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis. (cited information)
Formal Description
Interaction-ID: 9589

gene/protein

14-3-3 protein

increases_activity of

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment 14-3-3 proteins have long been acknowledged to stimulate the activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis. (cited information)
Formal Description
Interaction-ID: 9590

gene/protein

TH

increases_quantity of

drug/chemical compound

Dopamine

Drugbank entries Show/Hide entries for TH or Dopamine
Comment Three 14-3-3 isoforms, beta, eta, and zeta, have been shown to interact with and activate TH that is phosphorylated on Ser-19. (cited information)
Formal Description
Interaction-ID: 9591

gene/protein

YWHAB

interacts (colocalizes) with

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Three 14-3-3 isoforms, beta, eta, and zeta, have been shown to interact with and activate TH that is phosphorylated on Ser-19. (cited information)
Formal Description
Interaction-ID: 9592

gene/protein

YWHAH

interacts (colocalizes) with

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Three 14-3-3 isoforms, beta, eta, and zeta, have been shown to interact with and activate TH that is phosphorylated on Ser-19. (cited information)
Formal Description
Interaction-ID: 9593

gene/protein

YWHAZ

interacts (colocalizes) with

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Three 14-3-3 isoforms, beta, eta, and zeta, have been shown to interact with and activate TH that is phosphorylated on Ser-19. (cited information)
Formal Description
Interaction-ID: 9594

gene/protein

YWHAB

increases_activity of

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Three 14-3-3 isoforms, beta, eta, and zeta, have been shown to interact with and activate TH that is phosphorylated on Ser-19. (cited information)
Formal Description
Interaction-ID: 9595

gene/protein

YWHAH

increases_activity of

gene/protein

TH

Drugbank entries Show/Hide entries for TH
Comment Three 14-3-3 isoforms, beta, eta, and zeta, have been shown to interact with and activate TH that is phosphorylated on Ser-19. (cited information)
Formal Description
Interaction-ID: 9596

gene/protein

YWHAZ

increases_activity of

gene/protein

TH

Drugbank entries Show/Hide entries for TH