CIDeRplusGeneral Information:
| Id: | 1,377 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Mammalia | |
| review | |
| Reference: | Guglielmotto M et al.(2010) Oxidative stress mediates the pathogenic effect of different Alzheimers disease risk factors Front Aging Neurosci 2: 3 [PMID: 20552043] |
Interaction Information:
| Comment | It has been found that the phenoxy radical of Abeta Tyr-10 produced by the reaction with ROS causes neurotoxicity and results in the formation of dityrosines which, in turn, accelerate the aggregation of Abeta peptides. |
|
Formal Description Interaction-ID: 9527 |
drug/chemical compound Reactive oxygen species increases_quantity of gene/protein |