General Information:

Id: 1,360
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Kyratzi E et al.(2008) The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells Hum. Mol. Genet. 17: 2160-2171 [PMID: 18411255]

Interaction Information:

Comment WT UCH-L1 and mutant UCH-L1 S18Y or I19M (the mutant identified in PD) increase levels of monomeric ubiquitin in cells in a fashion dependent on the binding of UCH-L1 to ubiquitin.
Formal Description
Interaction-ID: 9298

gene/protein

UCHL1

increases_quantity of

gene/protein

Ubiquitin

Comment WT UCH-L1 and mutant UCH-L1 S18Y or I19M (the mutant identified in PD) increase levels of monomeric ubiquitin in cells in a fashion dependent on the binding of UCH-L1 to ubiquitin.
Formal Description
Interaction-ID: 9303

gene/protein mutant

UCHL1-p.S18Y

increases_quantity of

gene/protein

Ubiquitin

Comment WT UCH-L1 and mutant UCH-L1 S18Y or I19M (the mutant identified in PD) increase levels of monomeric ubiquitin in cells in a fashion dependent on the binding of UCH-L1 to ubiquitin.
Formal Description
Interaction-ID: 9304

gene/protein mutant

UCHL1-p.I93M

increases_quantity of

gene/protein

Ubiquitin

Comment UCH-L1 does not significantly associate with the proteasome in SH-SY5Y cell line.
Formal Description
Interaction-ID: 9306

gene/protein

UCHL1

NOT interacts (colocalizes) with

complex/PPI

26S proteasome

in SH-SY5Y cells
Comment UCH-L1 does not alter UPS function in SH-SY5Y cell line.
Formal Description
Interaction-ID: 9307

gene/protein

UCHL1

NOT affects_activity of

process

proteasome-mediated ubiquitin-dependent protein catabolic process

in SH-SY5Y cells
Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9309

drug/chemical compound

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9310

gene/protein

UCHL1

NOT decreases_quantity of

drug/chemical compound

Reactive oxygen species

after treatment with MPTP
Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9311

gene/protein mutant

UCHL1-p.S18Y

decreases_quantity of

drug/chemical compound

Reactive oxygen species

after treatment with MPTP
Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9312

gene/protein mutant

UCHL1-p.S18Y

decreases_activity of

drug/chemical compound

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9313

gene/protein mutant

UCHL1-p.S18Y

decreases_activity of

process

neuron death

after treatment with MPTP, via reduction of ROS
Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9316

gene/protein mutant

UCHL1-p.S18Y

decreases_activity of

process

response to oxidative stress

after treatment with MPTP, via reduction of ROS
Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9317

gene/protein mutant

UCHL1-p.S18Y

decreases_activity of

drug/chemical compound

H2O2

Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9496

drug/chemical compound

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

increases_activity of

process

response to oxidative stress