General Information:

Id: 1,357
Diseases: Amyotrophic lateral sclerosis
Mus musculus
Wild-type (WT), CX3CR1-EGFP, Nox1, and gp91phox/Nox2 knock-out (KO) mice
BTO:0000078 microglia
article
Reference: Cheret C et al.(2008) Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J. Neurosci. 28 [PMID: 19005069]

Interaction Information:

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9258

complex/PPI

NADPH oxidase complex

is localized in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9263

gene/protein

NOX1

is_expressed_in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9265

gene/protein

CYBA

is_expressed_in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9266

gene/protein

NOXO1

is_expressed_in

tissue/cell line

microglia

Drugbank entries Show/Hide entries for NOXO1
Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9267

gene/protein

NOXA1

is_expressed_in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9268

gene/protein

RAC1

is_expressed_in

tissue/cell line

microglia

Drugbank entries Show/Hide entries for RAC1
Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9269

gene/protein

RAC2

is_expressed_in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9270

gene/protein

CYBB

is_expressed_in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9271

gene/protein

NCF1

is_expressed_in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9272

gene/protein

NCF2

is_expressed_in

tissue/cell line

microglia

Comment Microglia express in vivo and in vitro the genes encoding the components of Nox1 (including the p22phox, NOXO1, NOXA1, and Rac1/2)- and Nox2 (including p40phox, 47phox and p67phox) -dependent NADPH oxidases.
Formal Description
Interaction-ID: 9273

gene/protein

NCF4

is_expressed_in

tissue/cell line

microglia

Comment Nox2 plays a prominent role in LPS-triggered microglial generation of Superoxide anion (O2.-). Nox1 is also implicated in LPS-stimulated O2.- production.
Formal Description
Interaction-ID: 9274

gene/protein

CYBB

increases_quantity of

drug/chemical compound

O2-

in microglia; induced by LPS
Comment Nox2 plays a prominent role in LPS-triggered microglial generation of Superoxide anion (O2.-). Nox1 is also implicated in LPS-stimulated O2.- production.
Formal Description
Interaction-ID: 9275

gene/protein

NOX1

increases_quantity of

drug/chemical compound

O2-

in microglia; induced by LPS
Comment Comparisons of LPS-treated microglia purified from WT, Nox2-KO, or Nox1-KO mice indicate that both Nox1 and Nox2 are required to optimize microglial production of nitric oxide.
Formal Description
Interaction-ID: 9277

gene/protein

NOX1

increases_quantity of

drug/chemical compound

NO

in microglia; induced by LPS
Comment Comparisons of LPS-treated microglia purified from WT, Nox2-KO, or Nox1-KO mice indicate that both Nox1 and Nox2 are required to optimize microglial production of nitric oxide.
Formal Description
Interaction-ID: 9278

gene/protein

CYBB

increases_quantity of

drug/chemical compound

NO

in microglia; induced by LPS
Comment Nox1 promotes iNOS expression and nitric oxide production, at least in Nox2-KO microglia.
Formal Description
Interaction-ID: 9279

gene/protein

NOX1

increases_expression of

gene/protein

NOS2

in microglia; induced by LPS
Drugbank entries Show/Hide entries for NOS2
Comment Nox1 activity promotes the LPS-induced IL-1-beta secretion at the transcriptional level or enhances the stability of IL-1-beta transcript. The loss of Nox2 does not significantly alter Nox1 regulation of IL-1-beta.
Formal Description
Interaction-ID: 14422

gene/protein

NOX1

increases_expression of

gene/protein

IL1B

in microglia; induced by LPS
Drugbank entries Show/Hide entries for IL1B