CIDeRplusGeneral Information:
| Id: | 1,344 |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mammalia | |
| SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A | |
| microglia (mouse) / motoneuron (rat) co-cultures | |
| article | |
| Reference: | Xiao Q et al.(2007) Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J. Neurochem. 102: 2008-2019 [PMID: 17555556] |
Interaction Information:
| Comment | More nitric oxide and less IGF-1 were detected in mSOD1(G93A) microglia co-cultured with motoneurons (mSOD1G93A-Mc + MN) than wild-type microglia co-cultured with motoneurons. |
|
Formal Description Interaction-ID: 9166 |
gene/protein mutant increases_quantity of drug/chemical compound |
| Comment | More nitric oxide and less IGF-1 were detected in mSOD1(G93A) microglia co-cultured with motoneurons (mSOD1G93A-Mc + MN) than wild-type microglia co-cultured with motoneurons. |
|
Formal Description Interaction-ID: 9167 |
gene/protein mutant decreases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for IGF1 |
| Comment | In microglia/motoneuron co-cultures, mSOD1(G93A) microglia induced more motoneuron death and decreased neurite numbers and length compared with wild-type microglia. |
|
Formal Description Interaction-ID: 9168 |
gene/protein mutant increases_activity of phenotype |
| Comment | In microglia/motoneuron co-cultures, mSOD1(G93A) microglia induced more motoneuron death and decreased neurite numbers and length compared with wild-type microglia. |
|
Formal Description Interaction-ID: 9169 |
gene/protein mutant decreases_activity of process |
| Comment | There was a strong inverse correlation between the level of nitric oxide release and motoneuron injury. The more nitrate + nitrite produced, the fewer motoneuron survived in mSOD1G93A and wild-type-co-cultures. |
|
Formal Description Interaction-ID: 9170 |
drug/chemical compound increases_activity of phenotype |