General Information:

Id: 1,343
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
BTO:0000078 microglia
article
Reference: Xiao Q et al.(2007) Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J. Neurochem. 102: 2008-2019 [PMID: 17555556]

Interaction Information:

Comment Mutant mSOD1(G93A) microglia are more responsive to stimuli than wild-type microglia. Following activation with lipopolysaccharide, mSOD1(G93A) microglia released more nitric oxide, more superoxide, and less insulin-like growth factor-1 than wild-type microglia.
Formal Description
Interaction-ID: 9161

drug/chemical compound

Lipopolysaccharide

increases_activity of

gene/protein mutant

SOD1-p.G93A

in microglia
Comment Mutant mSOD1(G93A) microglia are more responsive to stimuli than wild-type microglia. Following activation with lipopolysaccharide (LPS), mSOD1(G93A) microglia released more nitric oxide, more superoxide, and less insulin-like growth factor-1 than wild-type microglia.
Formal Description
Interaction-ID: 9162

gene/protein mutant

SOD1-p.G93A

increases_quantity of

drug/chemical compound

NO

in microglia; induced by LPS
Comment Following activation with lipopolysaccharide (LPS) mSOD1G93A microglia expressed 170% more iNOS than wild-type microglia.
Formal Description
Interaction-ID: 9163

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

NOS2

in microglia; induced by LPS
Drugbank entries Show/Hide entries for NOS2
Comment Mutant mSOD1(G93A) microglia are more responsive to stimuli than wild-type microglia. Following activation with lipopolysaccharide (LPS), mSOD1(G93A) microglia released more nitric oxide, more superoxide, and less insulin-like growth factor-1 than wild-type microglia.
Formal Description
Interaction-ID: 9164

gene/protein mutant

SOD1-p.G93A

increases_quantity of

drug/chemical compound

O2-

in microglia; induced by LPS
Comment Mutant mSOD1(G93A) microglia are more responsive to stimuli than wild-type microglia. Following activation with lipopolysaccharide (LPS), mSOD1(G93A) microglia released more nitric oxide, more superoxide, and less insulin-like growth factor-1 than wild-type microglia. Wild-type microglia released more free IGF-1 than microglia from mSOD1(G93A) transgenic mice, either with or without LPS stimulation.
Formal Description
Interaction-ID: 9165

gene/protein mutant

SOD1-p.G93A

decreases_quantity of

gene/protein

IGF1

in microglia; with or without LPS stimulation
Drugbank entries Show/Hide entries for IGF1
Comment Microglial activation can be associated with increased production of potentially cytotoxic substances, such as nitric oxide, superoxide, and pro-inflammatory cytokines.
Formal Description
Interaction-ID: 9171

drug/chemical compound

NO

affects_activity of

process

microglial cell activation

Comment Microglial activation can be associated with increased production of potentially cytotoxic substances, such as nitric oxide, superoxide, and pro-inflammatory cytokines.
Formal Description
Interaction-ID: 14413

drug/chemical compound

O2-

affects_activity of

process

microglial cell activation