CIDeRplusGeneral Information:
| Id: | 1,314 |
| Diseases: |
Epilepsy, temporal lobe
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| Mammalia | |
| review | |
| Reference: | Waldbaum S and Patel M(2010) Mitochondria, oxidative stress, and temporal lobe epilepsy Epilepsy Res. 88: 23-45 [PMID: 19850449] |
Interaction Information:
| Comment | Kainate (KA) -induced seizures have been shown to initially increase complex IV activity, the terminal enzyme complex of the mitochondrial ETC, and complex IV subunit mRNA 1 h post-SE in the amygdala, hippocampus, and frontal cortex which decreased by 3d in the amygdala and hip- pocampus. |
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Formal Description Interaction-ID: 8974 |
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| Comment | In studies where KA was administered directly into CA3 producing seizures and ictal electroencephalogram (EEG) activity, depressed activity of nicotinamide adenine dinucleotide cytochrome c reductase (NCCR), a marker for complexes I and III, was observed at 180min post-injection in all hippocampal subfields while succinate cytochrome c reductase, a marker for complexes II and III, and complex IV remained unaltered. |
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Formal Description Interaction-ID: 8976 |
phenotype NOT affects_activity of complex/PPI Mitochondrial respiratory chain complex II |
| Comment | These changes were accompanied by swelling of mitochondrial spaces and membrane disruption, suggesting that complex I enzyme dysfunction and mitochondrial ultrastructural damage in the hippocampus were associated with prolonged seizures. |
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Formal Description Interaction-ID: 8977 |
phenotype affects_activity of phenotype |
| Comment | Results from the pilocarpine model have demonstrated decreased activity of complexes I and IV, increased flux control of complex I and decreased respiration rates in CA1 and CA3 30 d post-treatment, with no changes detected in the dentate gyrus or parahippocampal gyrus. |
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Formal Description Interaction-ID: 8978 |
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| Drugbank entries | Show/Hide entries for Pilocarpine |
| Comment | Forty five days post-pilocarpine-induced SE, mitochondrial encoded complex IV subunit III decreased while nuclear encoded subunit IV remained unchanged along with nuclear encoded complex II in the hippocampus. |
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Formal Description Interaction-ID: 8979 |
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| Drugbank entries | Show/Hide entries for MT-CO3 |
| Comment | Evidence from the kindling model has shown a transient decrease in complex I activity at 16 h in CA3 and an increase in complexes II and III activity, which may be an attempt to upregulate mitochondrial ETC activity and compensate for a deficiency in complex I. |
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Formal Description Interaction-ID: 8980 |
phenotype decreases_activity of complex/PPI Mitochondrial respiratory chain complex II |
| Comment | Kainate-induced seizures have been shown to initially increase complex IV activity, the terminal enzyme complex of the mitochondrial ETC, and complex IV subunit mRNA 1 h post-SE in the amygdala, hippocampus, and frontal cortex which decreased by 3d in the amygdala and hippocampus. |
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Formal Description Interaction-ID: 9025 |
phenotype increases_activity of gene/protein |
| Drugbank entries | Show/Hide entries for COX4I1 |
| Comment | Kainate-induced seizures have been shown to initially increase complex IV activity, the terminal enzyme complex of the mitochondrial ETC, and complex IV subunit mRNA 1 h post-SE in the amygdala, hippocampus, and frontal cortex which decreased by 3d in the amygdala and hippocampus. |
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Formal Description Interaction-ID: 9026 |
phenotype increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for COX4I1 |
| Comment | Kainate-induced seizures have been shown to initially increase complex IV activity, the terminal enzyme complex of the mitochondrial ETC, and complex IV subunit mRNA 1 h post-SE in the amygdala, hippocampus, and frontal cortex which decreased by 3d in the amygdala and hippocampus. |
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Formal Description Interaction-ID: 9027 |
phenotype decreases_activity of gene/protein |
| Drugbank entries | Show/Hide entries for COX4I1 |
| Comment | In studies where KA was administered directly into CA3 producing seizures and ictal electroencephalogram (EEG) activity, depressed activity of nicotinamide adenine dinucleotide cytochrome c reductase (NCCR), a marker for complexes I and III, was observed at 180min post-injection in all hippocampal subfields while succinate cytochrome c reductase, a marker for complexes II and III, and complex IV remained unaltered. |
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Formal Description Interaction-ID: 9028 |
phenotype decreases_activity of complex/PPI Mitochondrial respiratory chain complex I |
| Comment | These changes were accompanied by swelling of mitochondrial spaces and membrane disruption, suggesting that complex I enzyme dysfunction and mitochondrial ultrastructural damage in the hippocampus were associated with prolonged seizures. |
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Formal Description Interaction-ID: 9038 |
phenotype affects_activity of complex/PPI Mitochondrial respiratory chain complex I |
| Comment | Results from the pilocarpine model have demonstrated decreased activity of complexes I and IV, increased flux control of complex I and decreased respiration rates in CA1 and CA3 30 d post-treatment, with no changes detected in the dentate gyrus or parahippocampal gyrus. |
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Formal Description Interaction-ID: 9039 |
phenotype decreases_activity of complex/PPI Mitochondrial respiratory chain complex I |
| Comment | Results from the pilocarpine model have demonstrated decreased activity of complexes I and IV, increased flux control of complex I and decreased respiration rates in CA1 and CA3 30 d post-treatment, with no changes detected in the dentate gyrus or parahippocampal gyrus. |
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Formal Description Interaction-ID: 9040 |
phenotype decreases_activity of complex/PPI Mitochondrial respiratory chain complex III |
| Comment | Results from the pilocarpine model have demonstrated decreased activity of complexes I and IV, increased flux control of complex I and decreased respiration rates in CA1 and CA3 30 d post-treatment, with no changes detected in the dentate gyrus or parahippocampal gyrus. |
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Formal Description Interaction-ID: 9041 |
phenotype affects_activity of |
| Comment | Forty five days post-pilocarpine-induced SE, mitochondrial encoded complex IV subunit III decreased while nuclear encoded subunit IV remained unchanged along with nuclear encoded complex II in the hippocampus. |
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Formal Description Interaction-ID: 9042 |
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| Drugbank entries | Show/Hide entries for COX4I1 |
| Comment | Evidence from the kindling model has shown a transient decrease in complex I activity at 16 h in CA3 and an increase in complexes II and III activity, which may be an attempt to upregulate mitochondrial ETC activity and compensate for a deficiency in complex I. |
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Formal Description Interaction-ID: 9043 |
phenotype decreases_activity of complex/PPI Mitochondrial respiratory chain complex III |
| Comment | Evidence from the kindling model has shown a transient decrease in complex I activity at 16 h in CA3 and an increase in complexes II and III activity, which may be an attempt to upregulate mitochondrial ETC activity and compensate for a deficiency in complex I. |
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Formal Description Interaction-ID: 9044 |
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