General Information:

Id: 1,309
Diseases: Alzheimer disease - [OMIM]
Mus musculus
aged B6-R1.40 mice
article
Reference: Wilkinson BL et al.(2012) Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimers disease Neurobiol. Aging 33: 197 [PMID: 20696495]

Interaction Information:

Comment A 9-month Ibuprofen treatment of aged R1.40 mice resulted in 90% decrease in plaque burden and a similar reduction in microglial activation.
Formal Description
Interaction-ID: 8942

drug/chemical compound

Ibuprofen

decreases_quantity of

phenotype

amyloid beta deposits

Chronic ibuprofen treatment reduces AD-related plaque pathology in B6-R1.40 mice.
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Comment Ibuprofen treatment reduced the levels of lipid peroxidation.
Formal Description
Interaction-ID: 8943

drug/chemical compound

Ibuprofen

decreases_activity of

process

lipid peroxidation

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Comment A 9-month Ibuprofen treatment of aged R1.40 mice resulted in 90% decrease in plaque burden and a similar reduction in microglial activation.
Formal Description
Interaction-ID: 8944

drug/chemical compound

Ibuprofen

decreases_activity of

process

microglial cell activation

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Comment Ibuprofen treatment reduced the level of protein oxidation.
Formal Description
Interaction-ID: 8945

drug/chemical compound

Ibuprofen

decreases_activity of

process

protein oxidation

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Comment Ibuprofen treatment reduced the level of tyrosine nitration. The nitration of tyrosine residues is the result of the highly reactive peroxynitrite radical, which is produced by a reaction of nitric oxide with their superoxide anion. The nitration of tyrosine residues in proteins compromises their action in cellular signaling an alters protein structure.
Formal Description
Interaction-ID: 8996

drug/chemical compound

Ibuprofen

decreases_activity of

process

tyrosine nitration

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Comment Chronic ibuprofen treatment decreased AD-related oxidative damage.
Formal Description
Interaction-ID: 8997

drug/chemical compound

Ibuprofen

affects_activity of

process

response to oxidative stress

induced by AD
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Comment Ibuprofen inhibited fibrillar beta-amyloid-stimulated ROS production in primary microglia.
Formal Description
Interaction-ID: 8998

drug/chemical compound

Ibuprofen

decreases_quantity of

drug/chemical compound

Reactive oxygen species

in primary microglia; if ROS-production is stimulated by fibrillar amyloid beta peptides
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Comment Chronic ibuprofen treatment decreased AD-related oxidative damage.
Formal Description
Interaction-ID: 20817

drug/chemical compound

Ibuprofen

decreases_activity of

process

response to oxidative stress

induced by AD
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