General Information:

Id: 1,287
Diseases: Parkinson disease
Mus musculus
article
Reference: Chung YC et al.(2010) The role of neuroinflammation on the pathogenesis of Parkinsons disease BMB Rep 43: 225-232 [PMID: 20423606]

Interaction Information:

Comment Fluoxetine reduced superoxide generation in MPTP-treated mice.
Formal Description
Interaction-ID: 8748

drug/chemical compound

Fluoxetine

decreases_quantity of

drug/chemical compound

O2-

after MPTP treatment
Drugbank entries Show/Hide entries for Fluoxetine
Comment Fluoxetine reduced superoxide generation in MPTP-treated mice.
Formal Description
Interaction-ID: 8749

drug/chemical compound

Fluoxetine

decreases_activity of

drug/chemical compound

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Drugbank entries Show/Hide entries for Fluoxetine
Comment Fluoxetine inhibited the activation of microglia-derived NADPH oxidase as a major source of ROS generation at 2 days after nigral LPS injection.
Formal Description
Interaction-ID: 8750

drug/chemical compound

Lipopolysaccharide

increases_activity of

complex/PPI

NADPH oxidase complex

Comment Fluoxetine inhibited the activation of microglia-derived NADPH oxidase as a major source of ROS generation at 2 days after nigral LPS injection.
Formal Description
Interaction-ID: 8751

drug/chemical compound

Fluoxetine

decreases_activity of

complex/PPI

NADPH oxidase complex

after LPS treatment
Drugbank entries Show/Hide entries for Fluoxetine
Comment Fluoxetine inhibited the activation of microglia-derived NADPH oxidase as a major source of ROS generation at 2 days after nigral LPS injection.
Formal Description
Interaction-ID: 8752

complex/PPI

NADPH oxidase complex

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment Fluoxetine reduced superoxide generation in MPTP-treated mice.
Formal Description
Interaction-ID: 8753

drug/chemical compound

Fluoxetine

decreases_activity of

process

neuron death

after MPTP treatment
Drugbank entries Show/Hide entries for Fluoxetine
Comment Paroxetine, another anti-depressant, had neuroprotective effects on DA neurons.
Formal Description
Interaction-ID: 8754

drug/chemical compound

Paroxetine

decreases_activity of

process

neuron death

Drugbank entries Show/Hide entries for Paroxetine
Comment Capsaicin prevented neuronal death in MPTP and LPS models by inhibiting microglial activation and production of proinflammatory cytokines.
Formal Description
Interaction-ID: 8755

drug/chemical compound

Capsaicin

decreases_activity of

process

neuron death

after MPTP and LPS treatment
Comment Capsaicin prevented neuronal death in MPTP and LPS models by inhibiting microglial activation and production of proinflammatory cytokines.
Formal Description
Interaction-ID: 8756

drug/chemical compound

Capsaicin

decreases_activity of

process

microglial cell activation

after MPTP and LPS treatment