General Information:

Id: 1,286
Diseases: Parkinson disease
Rattus norvegicus
mesencephalic neuron-glia culture
article
Reference: Liu Y et al.(2003) Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation J. Pharmacol. Exp. Ther. 305: 212-218 [PMID: 12649371]

Interaction Information:

Comment Dextromethorphan, an ingredient widely used in antitussive remedies, reduced the inflammation-mediated degeneration of dopaminergic neurons through inhibition of microglial activation.
Formal Description
Interaction-ID: 8742

drug/chemical compound

Dextromethorphan

decreases_activity of

process

inflammatory response

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Comment Dextromethorphan, an ingredient widely used in antitussive remedies, reduced the inflammation-mediated degeneration of dopaminergic neurons through inhibition of microglial activation.
Formal Description
Interaction-ID: 8743

drug/chemical compound

Dextromethorphan

decreases_activity of

process

microglial cell activation

Drugbank entries Show/Hide entries for Dextromethorphan
Comment Dextromethorphan, an ingredient widely used in antitussive remedies, reduced the inflammation-mediated degeneration of dopaminergic neurons through inhibition of microglial activation.
Formal Description
Interaction-ID: 8744

drug/chemical compound

Dextromethorphan

decreases_activity of

process

neuron death

of dopaminergic neurons
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Comment Dextromethorphan significantly inhibited the LPS-induced production of tumor necrosis factor-alpha, nitric oxide, and superoxide free radicals.
Formal Description
Interaction-ID: 8745

drug/chemical compound

Dextromethorphan

decreases_quantity of

gene/protein

TNF

after induction of TNFalpha via LPS addition
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Comment Dextromethorphan significantly inhibited the LPS-induced production of tumor necrosis factor-alpha, nitric oxide, and superoxide free radicals.
Formal Description
Interaction-ID: 8746

drug/chemical compound

Dextromethorphan

decreases_quantity of

drug/chemical compound

NO

after induction of NO via LPS addition
Drugbank entries Show/Hide entries for Dextromethorphan
Comment Dextromethorphan significantly inhibited the LPS-induced production of tumor necrosis factor-alpha, nitric oxide, and superoxide free radicals.
Formal Description
Interaction-ID: 8747

drug/chemical compound

Dextromethorphan

decreases_quantity of

drug/chemical compound

O2-

after induction of NO via LPS addition
Drugbank entries Show/Hide entries for Dextromethorphan