General Information:

Id: 1,276
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0001279 spinal cord
article
Reference: Wu DC et al.(2006) The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice Proc. Natl. Acad. Sci. U.S.A. 103 [PMID: 16877542]

Interaction Information:

Comment Expression of NADPH oxidase (message and protein contents) in the spinal cord of symptomatic transgenic SOD1G93A mice, determined by analyzing its catalytic subunit, gp91phox, increased over time in concert with the development of a glial response.
Formal Description
Interaction-ID: 8694

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

CYBB

in spinal cord
Comment Expression of NADPH oxidase (message and protein contents) in the spinal cord of symptomatic transgenic SOD1G93A mice, determined by analyzing its catalytic subunit, gp91phox, increased over time in concert with the development of a glial response.
Formal Description
Interaction-ID: 8695

gene/protein mutant

SOD1-p.G93A

increases_quantity of

complex/PPI

NADPH oxidase complex

in spinal cord
Comment The levels of the p67phox subunit that contains the NADPH-binding site of the NADPH oxidase complex were increased in membrane fractions of spinal cord extracts from symptomatic transgenic SOD1G93A mice.
Formal Description
Interaction-ID: 8697

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

NCF2

in spinal cord
Comment Expression of NADPH oxidase (message and protein contents) in the spinal cord of symptomatic transgenic SOD1G93A mice, determined by analyzing its catalytic subunit, gp91phox, increased over time in concert with the development of a glial response.
Formal Description
Interaction-ID: 8700

gene/protein mutant

SOD1-p.G93A

increases_activity of

process

microglial cell activation

in spinal cord
Comment NADPH oxidase caused formation of ROS (reactive oxygen species) and protein oxidation in transgenic SOD1G93A mice.
Formal Description
Interaction-ID: 8703

complex/PPI

NADPH oxidase complex

increases_quantity of

drug/chemical compound

Reactive oxygen species

in spinal cord
Comment In addition to the prolonged survival, inactivation of NADPH oxidase did mitigate neurodegeneration.
Formal Description
Interaction-ID: 8717

complex/PPI

NADPH oxidase complex

increases_activity of

phenotype

motor neuron degeneration

in spinal cord
Comment Expression of NADPH oxidase (message and protein contents) in the spinal cord of symptomatic transgenic SOD1G93A mice, determined by analyzing its catalytic subunit, gp91phox, increased over time in concert with the development of a glial response.
Formal Description
Interaction-ID: 14279

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

CYBB

in spinal cord
Comment Expression of NADPH oxidase (message and protein contents) in the spinal cord of symptomatic transgenic SOD1G93A mice, determined by analyzing its catalytic subunit, gp91phox, increased over time in concert with the development of a glial response.
Formal Description
Interaction-ID: 14281

gene/protein

CYBB

is_part_of

complex/PPI

NADPH oxidase complex

in spinal cord
Comment The levels of the p67phox subunit that contains the NADPH-binding site of the NADPH oxidase complex were increased in membrane fractions of spinal cord extracts from symptomatic transgenic SOD1G93A mice.
Formal Description
Interaction-ID: 14282

gene/protein

NCF2

is_part_of

complex/PPI

NADPH oxidase complex

in spinal cord