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Field	Query

	Field	Term

General Information:

Id:	125
Diseases:	Parkinson disease
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000793 SHSY-5Y cell
Publication type:	article
Reference:	Parihar MS et al.(2008) Mitochondrial association of alpha-synuclein causes oxidative stress. Cell. Mol. Life Sci. 65: 1272-1284 [PMID: 18322646]

Interaction Information:

Comment	Overexpressed alpha-synuclein and mutant synuclein-A53T is mainly localized in mitochondria.
Formal Description Interaction-ID: 431	gene/protein SNCA is localized in cellular component mitochondrion if SNCA is overexpressed

Comment	Overexpressed alpha-synuclein and mutant synuclein-A53T is mainly localized in mitochondria.
Formal Description Interaction-ID: 432	gene/protein mutant SNCA-p.A53T is localized in cellular component mitochondrion if SNCA-p.A53T is overexpressed

Comment	Overexpresion of SNCA releases cytochrome c from mitochondria.
Formal Description Interaction-ID: 435	gene/protein SNCA increases_quantity of gene/protein CYCS in the cytoplasm; if SNCA is overexpressed
Drugbank entries	Show/Hide entries for CYCS
Drugbank DB01017	Minocycline negative modulator CYCS
Drugbank DB02110	Protoporphyrin Ix Containing Co not specified CYCS
Drugbank DB03014	Heme not specified CYCS
Drugbank DB03317	Heme C not specified CYCS
Drugbank DB03934	Protoporphyrin Ix Containing Zn not specified CYCS
Drugbank DB03977	N-Trimethyllysine not specified CYCS
Drugbank DB04249	Zinc Substituted Heme C not specified CYCS
Drugbank DB02110	Protoporphyrin Ix Containing Co not specified CYCS
Drugbank DB03014	Heme not specified CYCS
Drugbank DB03317	Heme C not specified CYCS
Drugbank DB03934	Protoporphyrin Ix Containing Zn not specified CYCS
Drugbank DB03977	N-Trimethyllysine not specified CYCS
Drugbank DB04249	Zinc Substituted Heme C not specified CYCS

Comment	Overexpresion of SNCA mutant A53T releases cytochrome c from mitochondria.
Formal Description Interaction-ID: 439	gene/protein mutant SNCA-p.A53T increases_quantity of gene/protein CYCS in the cytoplasm; if SNCA-p.A53T is overexpressed
Drugbank entries	Show/Hide entries for CYCS
Drugbank DB01017	Minocycline negative modulator CYCS
Drugbank DB02110	Protoporphyrin Ix Containing Co not specified CYCS
Drugbank DB03014	Heme not specified CYCS
Drugbank DB03317	Heme C not specified CYCS
Drugbank DB03934	Protoporphyrin Ix Containing Zn not specified CYCS
Drugbank DB03977	N-Trimethyllysine not specified CYCS
Drugbank DB04249	Zinc Substituted Heme C not specified CYCS
Drugbank DB02110	Protoporphyrin Ix Containing Co not specified CYCS
Drugbank DB03014	Heme not specified CYCS
Drugbank DB03317	Heme C not specified CYCS
Drugbank DB03934	Protoporphyrin Ix Containing Zn not specified CYCS
Drugbank DB03977	N-Trimethyllysine not specified CYCS
Drugbank DB04249	Zinc Substituted Heme C not specified CYCS

Comment	Overexpresion of SNCA increases amount of NO in mitochondria.
Formal Description Interaction-ID: 440	gene/protein SNCA increases_quantity of drug/chemical compound NO in mitochondria; if SNCA is overexpressed

Comment	Overexpresion of SNCA increases amount of CA2(+) in mitochondria.
Formal Description Interaction-ID: 449	gene/protein SNCA increases_quantity of drug/chemical compound Ca2+ in mitochondria; if SNCA is overexpressed

Comment	Overexpresion of SNCA releases cytochrome c from mitochondria.
Formal Description Interaction-ID: 13588	gene/protein SNCA increases_activity of process release of cytochrome c from mitochondria if SNCA is overexpressed

Comment	Overexpresion of SNCA mutant A53T releases cytochrome c from mitochondria.
Formal Description Interaction-ID: 13589	gene/protein mutant SNCA-p.A53T increases_activity of process release of cytochrome c from mitochondria if SNCA-p.A53T is overexpressed

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