General Information:

Id: 1,230
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000078 microglia
article
Reference: Min KJ et al.(2006) Astrocytes induce hemeoxygenase-1 expression in microglia: a feasible mechanism for preventing excessive brain inflammation J Neurosci 26: 1880-1887 [PMID: 16467537]

Interaction Information:

Comment Soluble factors released from astrocytes could suppress microglial ROS levels and that these soluble factors do not have direct ROS scavenging effect.
Formal Description
Interaction-ID: 8260

tissue/cell line

astrocyte

decreases_quantity of

drug/chemical compound

Reactive oxygen species

in microglia
Comment Soluble factors released from astrocytes modulate microglial ROS levels through incduction of HO-1 expression.
Formal Description
Interaction-ID: 8261

tissue/cell line

astrocyte

increases_expression of

gene/protein

HMOX1

in microglia
Drugbank entries Show/Hide entries for HMOX1
Comment Soluble factors released from astrocytes activate NRF2.
Formal Description
Interaction-ID: 8262

tissue/cell line

astrocyte

increases_activity of

gene/protein

NFE2L2

in microglia
Comment In microglia treated with IFN-gamma, iNOS protein expression was significantly suppressed in cells treated with ACM compared with non-pretreated cells.
Formal Description
Interaction-ID: 8263

gene/protein

IFNG

increases_quantity of

gene/protein

NOS2

in microglia
Drugbank entries Show/Hide entries for IFNG or NOS2
Comment In microglia treated with IFN-gamma, iNOS protein expression was significantly suppressed in cells treated with ACM compared with non-pretreated cells.
Formal Description
Interaction-ID: 8264

tissue/cell line

astrocyte

decreases_quantity of

gene/protein

NOS2

in microglia; after induction of iNOS via interferon-gamma
Drugbank entries Show/Hide entries for NOS2
Comment Soluble factors released from astrocytes suppressed NO production.
Formal Description
Interaction-ID: 8265

tissue/cell line

astrocyte

decreases_quantity of

drug/chemical compound

NO

in microglia
Comment HO-1 products mimic the anti-inflammatory roles of astrocytes.
Formal Description
Interaction-ID: 8266

gene/protein

HMOX1

decreases_activity of

process

inflammatory response

Drugbank entries Show/Hide entries for HMOX1
Comment Astrocytes regulate excessive inflammation via induction of microglial hemooxygenase-1 (HO-1).
Formal Description
Interaction-ID: 8267

tissue/cell line

astrocyte

decreases_activity of

process

inflammatory response

via induction of microglial HO-1