General Information:

Id: 1,226
Diseases: Schizophrenia - [OMIM]
Homo sapiens
BTO:0000131 blood plasma
article
Reference: Cai HL et al.(2010) Elevated plasma gamma-aminobutyrate/glutamate ratio and responses to risperidone antipsychotic treatment in schizophrenia Prog. Neuropsychopharmacol. Biol. Psychiatry 34: 1273-1278 [PMID: 20637820]

Interaction Information:

Comment Plasma levels of GABA and Glu were significantly lower in schizophrenia patients than in controls.
Formal Description
Interaction-ID: 8240

disease

Schizophrenia

decreases_quantity of

drug/chemical compound

GABA

in blood plasma
Comment Plasma levels of GABA and Glu were significantly lower in schizophrenia patients than in controls.
Formal Description
Interaction-ID: 8241

disease

Schizophrenia

decreases_quantity of

drug/chemical compound

Glutamate

in blood plasma
Comment During treatment with risperidone a non-significant further decrease of plasma GABA, a significant increase of plasma Glu and a significant reduction of plasma GABA/Glu ratio were observed.
Formal Description
Interaction-ID: 8242

drug/chemical compound

Risperidone

increases_quantity of

drug/chemical compound

Glutamate

Drugbank entries Show/Hide entries for Risperidone
Comment Plasma levels of GABA and Glu were significantly lower in schizophrenia patients than in controls.
Formal Description
Interaction-ID: 8243

drug/chemical compound

Risperidone

decreases_quantity of

drug/chemical compound

GABA

Drugbank entries Show/Hide entries for Risperidone