CIDeRplusGeneral Information:
| Id: | 1,215 |
| Diseases: |
Parkinson disease
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| Mus musculus | |
| article/cited | |
| Reference: | Su X et al.(2008) Synuclein activates microglia in a model of Parkinsons disease Neurobiol. Aging 29: 1690-1701 [PMID: 17537546] |
Interaction Information:
| Comment | Microglia along with astrocytes comprise the innate immune response in the brain. (cited information) |
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Formal Description Interaction-ID: 8160 |
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| Comment | Microglia along with astrocytes comprise the innate immune response in the brain. (cited information) |
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Formal Description Interaction-ID: 8161 |
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| Comment | Activation of microglia is accompanied by alterations in cell surface receptor expression, increased reactive oxygen species (ROS) production and release of chemokines and cytokines, such as TNFalpha and IL1beta. (cited information) |
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Formal Description Interaction-ID: 8162 |
process increases_quantity of drug/chemical compound Reactive oxygen species |
| Comment | Activation of microglia is accompanied by alterations in cell surface receptor expression, increased reactive oxygen species (ROS) production and release of chemokines and cytokines, such as TNFalpha and IL1beta. (cited information) |
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Formal Description Interaction-ID: 8163 |
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| Drugbank entries | Show/Hide entries for TNF |
| Comment | Activation of microglia is accompanied by alterations in cell surface receptor expression, increased reactive oxygen species (ROS) production and release of chemokines and cytokines, such as TNFalpha and IL1beta. |
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Formal Description Interaction-ID: 8164 |
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| Drugbank entries | Show/Hide entries for IL1B |
| Comment | Activated microglia can phagocytose foreign antigens, proliferate and recruit additional microglia to mediate the inflammatory response. (cited information) |
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Formal Description Interaction-ID: 8165 |
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| Comment | SYN could activate microglia through a direct interaction or indirectly through release of neuronal-derived soluble factors. (cited information) |
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Formal Description Interaction-ID: 8173 |
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| Comment | Microglial activation is accompanied by an increase in the production of various cytokines, including IL1beta and IL6 as well as inflammation-related enzymes, such as cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS/NOS2). (cited information) |
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Formal Description Interaction-ID: 8185 |
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| Drugbank entries | Show/Hide entries for IL1B |
| Comment | Microglial activation is accompanied by an increase in the production of various cytokines, including IL1beta and IL6 as well as inflammation-related enzymes, such as cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS/NOS2). (cited information) |
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Formal Description Interaction-ID: 8186 |
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| Drugbank entries | Show/Hide entries for IL6 |
| Comment | Microglial activation is accompanied by an increase in the production of various cytokines, including IL1beta and IL6 as well as inflammation-related enzymes, such as cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS/NOS2). (cited information) |
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Formal Description Interaction-ID: 8187 |
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| Drugbank entries | Show/Hide entries for PTGS2 |
| Comment | Microglial activation is accompanied by an increase in the production of various cytokines, including IL1beta and IL6 as well as inflammation-related enzymes, such as cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS/NOS2). (cited information) |
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Formal Description Interaction-ID: 8188 |
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| Drugbank entries | Show/Hide entries for NOS2 |
| Comment | Microglial activation is accompanied by an increase in the production of various cytokines, including IL1beta and IL6 as well as inflammation-related enzymes, such as cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS/NOS2). (cited information) |
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Formal Description Interaction-ID: 8189 |
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| Drugbank entries | Show/Hide entries for PTGS2 |
| Comment | Microglial activation is accompanied by an increase in the production of various cytokines, including IL1beta and IL6 as well as inflammation-related enzymes, such as cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS/NOS2). (cited information) |
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Formal Description Interaction-ID: 8190 |
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| Drugbank entries | Show/Hide entries for NOS2 |