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General Information:

Id:	116 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000007 HEK-293 cell
Publication type:	article
Reference:	Alessi DR et al.(1996) Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15: 6541-6551 [PMID: 8978681]

Comment	MAPKAP kinase-2 phosphorylates Ser473 of AKT1 causing partial activation.
Formal Description Interaction-ID: 404	gene/protein MAPKAPK2 increases_activity of gene/protein AKT1 by phosphorylation at Ser473
Drugbank entries	Show/Hide entries for MAPKAPK2 or AKT1
Drugbank DB02010	Staurosporine not specified MAPKAPK2
Drugbank DB03431	Adenosine-5'-Diphosphate not specified MAPKAPK2
Drugbank DB07234	3-{[(1R)-1-phenylethyl]amino}-4-(pyridin ... not specified MAPKAPK2
Drugbank DB07406	(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMIN ... not specified MAPKAPK2
Drugbank DB07430	(10R)-10-methyl-3-(6-methylpyridin-3-yl) ... not specified MAPKAPK2
Drugbank DB07431	(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-t ... not specified MAPKAPK2
Drugbank DB07728	2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6 ... not specified MAPKAPK2
Drugbank DB08358	2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7- ... not specified MAPKAPK2
Drugbank DB02010	Staurosporine not specified MAPKAPK2
Drugbank DB03431	Adenosine-5'-Diphosphate not specified MAPKAPK2
Drugbank DB00171	Adenosine triphosphate not specified AKT1
Drugbank DB01169	Arsenic trioxide inducer AKT1
Drugbank DB01863	Inositol 1,3,4,5-Tetrakisphosphate not specified AKT1
Drugbank DB07584	N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phe ... not specified AKT1
Drugbank DB07585	5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4 ... not specified AKT1
Drugbank DB00171	Adenosine triphosphate not specified AKT1
Drugbank DB01863	Inositol 1,3,4,5-Tetrakisphosphate not specified AKT1